2024
Steady Hands, Heavy Hearts and the Path Forward to Moral Resilience in Organ Transplantation
Batra R, Latham S, Gerber D. Steady Hands, Heavy Hearts and the Path Forward to Moral Resilience in Organ Transplantation. The American Journal Of Bioethics 2024, 24: 40-42. PMID: 39565243, DOI: 10.1080/15265161.2024.2416131.Peer-Reviewed Original Research
2023
Meaningful Residual Function, Permanence and Brain Death
Batra R, Latham S. Meaningful Residual Function, Permanence and Brain Death. AJOB Neuroscience 2023, 14: 269-271. PMID: 37682666, DOI: 10.1080/21507740.2023.2243891.Peer-Reviewed Original ResearchA randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel groupThe Ethics and Politics of Healthcare Resource Allocation During Covid
Latham S. The Ethics and Politics of Healthcare Resource Allocation During Covid. The International Library Of Bioethics 2023, 106: 329-339. DOI: 10.1007/978-3-031-39973-2_20.Peer-Reviewed Original Research
2022
Cellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsA Hub and Spoke Model for Improving Access and Standardizing Ethics Consultations Across a Large Healthcare System
Tolchin B, Bruce L, Mercurio M, Latham SR. A Hub and Spoke Model for Improving Access and Standardizing Ethics Consultations Across a Large Healthcare System. The American Journal Of Bioethics 2022, 22: 42-45. PMID: 35420520, DOI: 10.1080/15265161.2022.2044551.Peer-Reviewed Original Research
2021
Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic.
Tolchin B, Latham SR, Bruce L, Ferrante LE, Kraschel K, Jubanyik K, Hull SC, Herbst JL, Kapo J, Moritz ED, Hughes J, Siegel MD, Mercurio MR. Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic. The Journal Of Clinical Ethics 2021, 32: 358-360. PMID: 34928864, DOI: 10.1086/jce2021324358.Commentaries, Editorials and LettersConceptsSOFA scoreBlack patientsCrisis standardsSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreAccurate prognostic scoresNext public health emergencyCOVID-19 patientsLife-saving medical resourcesMedical resourcesCOVID-19 pandemicSame scoring systemPublic health emergencyPrognostic scoreBody of evidenceRare casePatientsScoring systemTriage purposesAssessment scoresHealth emergencyCareHealthcare systemCOVID-19ScoresFrailty, an Imperfect ICU Rationing Criterion
Batra RK, Latham SR. Frailty, an Imperfect ICU Rationing Criterion. The American Journal Of Bioethics 2021, 21: 69-71. PMID: 34710005, DOI: 10.1080/15265161.2021.1980142.Peer-Reviewed Original ResearchViolations of Suicide-Prevention Guidelines in US Media Coverage of Physician's Suicide Death During the COVID-19 Pandemic
Lynn-Green E, Jaźwińska K, Beckman A, Latham S. Violations of Suicide-Prevention Guidelines in US Media Coverage of Physician's Suicide Death During the COVID-19 Pandemic. Crisis 2021, 43: 340-343. PMID: 33944606, DOI: 10.1027/0227-5910/a000778.Peer-Reviewed Original ResearchConceptsHealthcare workersSuicide deathsSuicide prevention guidelinesRisk of suicideSuicide reporting guidelinesCOVID-19 pandemicReporting guidelinesElevated riskSuicide guidelinesSubsequent suicideSuicide preventionUnique articlesDeathAdherenceRiskSuicideGuidelinesPandemicSuicide reportingThird of articlesElectronic health record alerts for acute kidney injury: multicenter, randomized clinical trial
Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial. The BMJ 2021, 372: m4786. PMID: 33461986, PMCID: PMC8034420, DOI: 10.1136/bmj.m4786.Peer-Reviewed Original ResearchConceptsAcute kidney injuryElectronic health record alertsKidney injuryPrimary outcomeMedical recordsYale New Haven Health SystemCare practicesGlobal Outcomes creatinine criteriaLarge tertiary care centerComposite of progressionDays of randomizationReceipt of dialysisPrespecified secondary outcomesTertiary care centerPatients' medical recordsSmall community hospitalNon-teaching hospitalsElectronic health recordsCreatinine criteriaUsual careSecondary outcomesAdult inpatientsKidney diseaseClinical centersWorse outcomes
2020
Molecular HIV Surveillance and Public Health Ethics: Old Wine in New Bottles
Dawson L, Latham S. Molecular HIV Surveillance and Public Health Ethics: Old Wine in New Bottles. The American Journal Of Bioethics 2020, 20: 39-41. PMID: 33016834, DOI: 10.1080/15265161.2020.1806393.Peer-Reviewed Original ResearchNon-Human Germline Interventions
Latham S. Non-Human Germline Interventions. The American Journal Of Bioethics 2020, 20: 23-25. PMID: 32804062, DOI: 10.1080/15265161.2020.1781976.Peer-Reviewed Original ResearchPersonal Transformation and Advance Directives: An Experimental Bioethics Approach
Earp B, Latham S, Tobia K. Personal Transformation and Advance Directives: An Experimental Bioethics Approach. The American Journal Of Bioethics 2020, 20: 72-75. PMID: 32757927, DOI: 10.1080/15265161.2020.1781964.Peer-Reviewed Original Research
2018
From Interest to Applause to Despair
Latham S. From Interest to Applause to Despair. The American Journal Of Bioethics 2018, 18: 15-17. PMID: 31159690, DOI: 10.1080/15265161.2018.1533737.Peer-Reviewed Original ResearchHuman–Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges
De Los Angeles A, Hyun I, Latham S, Elsworth J, Redmond D. Human–Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges. Stem Cells And Development 2018, 27: 1599-1604. PMID: 30319057, PMCID: PMC7366261, DOI: 10.1089/scd.2018.0162.Peer-Reviewed Original ResearchConceptsImportant ethical considerationsModeling Human DiseaseHuman PS cellsInterspecies chimerasUse of monkeysChimera researchEthical considerationsEthical concernsInvasive researchCell researchPolitical issuesScientific valueBiomedical researchLight of advancesHuman stem cellsJurisdictionsPS cellsHoly grailQuestionsAsymmetrical Intuitions
Latham S. Asymmetrical Intuitions. The American Journal Of Bioethics 2018, 18: 54-55. PMID: 30475189, DOI: 10.1080/15265161.2018.1523505.Peer-Reviewed Original Research
2017
Responsibility for Collateral Harm
Latham S. Responsibility for Collateral Harm. The American Journal Of Bioethics 2017, 17: 55-57. PMID: 29020563, DOI: 10.1080/15265161.2017.1366197.Peer-Reviewed Original Research
2016
Moral Distress and Cooperation With Wrongdoing
Latham S. Moral Distress and Cooperation With Wrongdoing. The American Journal Of Bioethics 2016, 16: 31-32. PMID: 27901422, DOI: 10.1080/15265161.2016.1240505.Peer-Reviewed Original ResearchLawrence Gostin's Enthusiastic Globalism
Latham S. Lawrence Gostin's Enthusiastic Globalism. The Hastings Center Report 2016, 46: 43-44. DOI: 10.1002/hast.646.Peer-Reviewed Original ResearchNorth Atlantic Treaty OrganizationXenophobic political partiesUnited States presidencyPolitical partiesInternational institutionsGlobal health lawNew immigrantsTreaty OrganizationUnited NationsEuropean UnionInternational health lawHealth lawGlobal tradeGlobalismInternational arbitrationInstitutionsTrade platformSubstantial bodySouth China SeaBrexitPresidencyImmigrantsHard dayPartiesVote
2015
Political Theory, Values and Public Health
Latham S. Political Theory, Values and Public Health. Public Health Ethics 2015, 9: 139-149. PMID: 27551295, PMCID: PMC4985895, DOI: 10.1093/phe/phv033.Peer-Reviewed Original Research