Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis
Ye H, Kaszuba S. Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis. Journal Of Biomedical Science 2017, 24: 93. PMID: 29202749, PMCID: PMC5715558, DOI: 10.1186/s12929-017-0399-8.Peer-Reviewed Original ResearchConceptsGABAergic interneuronsEpileptic circuitrySeizure suppressionGABA depletionSeizure controlExcitatory effectsGABAergic cellsGABAergic inhibitionNetwork hyperexcitabilityPyramidal neuronsNeuronal balancePyramidal cellsEpileptic circuitsInhibitory neuronsPostsynaptic neuronsGABA receptorsPostsynaptic cellInterneuronsOptogenetic excitationOptogenetic protocolsCircuitry levelEpileptogenesisOptogenetic interrogationInhibitory effectContext-dependent role