2019
Neuromodulation with electromagnetic stimulation for seizure suppression: From electrode to magnetic coil
Ye H, Kaszuba S. Neuromodulation with electromagnetic stimulation for seizure suppression: From electrode to magnetic coil. IBRO Neuroscience Reports 2019, 7: 26-33. PMID: 31360792, PMCID: PMC6639724, DOI: 10.1016/j.ibror.2019.06.001.Peer-Reviewed Original ResearchTreatment of epilepsyLong-term safetySeizure suppressionSynaptic transmissionEpileptic activityDepolarization blockadeMagnetic stimulationStimulation protocolAnimal modelsClinical casesEphaptic interactionsNeural activityImplanted electrodePathological situationsStimulationClinical translationElectromagnetic stimulationCellular synchronizationIon channelsMolecular mechanismsTissue stimulationMolecular studiesMembrane polarizationSafety issuesEpilepsy
2017
Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis
Ye H, Kaszuba S. Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis. Journal Of Biomedical Science 2017, 24: 93. PMID: 29202749, PMCID: PMC5715558, DOI: 10.1186/s12929-017-0399-8.Peer-Reviewed Original ResearchConceptsGABAergic interneuronsEpileptic circuitrySeizure suppressionGABA depletionSeizure controlExcitatory effectsGABAergic cellsGABAergic inhibitionNetwork hyperexcitabilityPyramidal neuronsNeuronal balancePyramidal cellsEpileptic circuitsInhibitory neuronsPostsynaptic neuronsGABA receptorsPostsynaptic cellInterneuronsOptogenetic excitationOptogenetic protocolsCircuitry levelEpileptogenesisOptogenetic interrogationInhibitory effectContext-dependent role