2015
Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys
Elsworth JD, Jentsch JD, Groman SM, Roth RH, Redmond ED, Leranth C. Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys. The Journal Of Comparative Neurology 2015, 523: 1248-1257. PMID: 25557059, PMCID: PMC4390445, DOI: 10.1002/cne.23735.Peer-Reviewed Original ResearchConceptsLevels of BPARegimen of exposureAdult male vervet monkeysExcitatory synaptic inputsAsymmetric spine synapsesAdult male monkeysImpact of BPADorsolateral prefrontal cortexPyramidal neuronsSpine synapsesSynaptic effectsCognitive dysfunctionMale vervet monkeysSynaptic inputsDendritic spinesPrimate brainExposure of humansMale monkeysBrain regionsCognitive deficitsLevels of bisphenolPrefrontal cortexAdverse effectsManufacture of plasticsStudies of humans
2014
Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex
Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE, Kim JD, Diano S, Roth RH. Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex. The International Journal Of Neuropsychopharmacology 2014, 18: pyu048. PMID: 25522392, PMCID: PMC4438537, DOI: 10.1093/ijnp/pyu048.Peer-Reviewed Original ResearchConceptsSpine synapse numberDorsolateral prefrontal cortexDopamine turnoverPhencyclidine treatmentSpine synapsesSynapse numberCognitive deficitsPrefrontal cortexPhencyclidine modelMale monkeysJuvenile monkeysSchizophrenia-related cognitive deficitsDendritic spine synapsesIncidence of schizophreniaAdult male monkeysSex-specific effectsMessenger RNABDNF expressionNeurotrophic factorNovel treatmentsCombined groupAdult nonhumanCore symptomsCortexNonhuman primates
2007
Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys
James AS, Groman SM, Seu E, Jorgensen M, Fairbanks LA, Jentsch JD. Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys. Journal Of Neuroscience 2007, 27: 14358-14364. PMID: 18160643, PMCID: PMC6673444, DOI: 10.1523/jneurosci.4508-07.2007.Peer-Reviewed Original ResearchConceptsDimensions of impulsivityMemory performanceNonsocial stimuliResponse taskImpulsive behaviorDRD4 genotypeAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderSpatial Working Memory PerformanceHigh impulsive animalsWorking Memory PerformanceDelayed response taskDimensions of temperamentLow impulsive subjectsDRD4 allelesNeurocognitive endophenotypesDopamine D4 receptor geneHyperactivity disorderD4 receptor geneDimensional phenotypesCorrect responsesDelay versionImpulsivityCeiling levelImpulsive approach