2022
MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV
Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Research Neuroimaging 2022, 321: 111445. PMID: 35101828, DOI: 10.1016/j.pscychresns.2022.111445.Peer-Reviewed Original ResearchConceptsGp120 transgenic miceWildtype miceTransgenic miceCognitive deficits persistElevated inflammatory profilesPositron emission tomography studyEmission tomography studiesElevated neuroinflammationNeuroinflammatory profileInflammatory profileInflammatory insultVentral striataHIV envelopeLipopolysaccharide treatmentHIV entryMouse modelHIVBehavioral abnormalitiesDeficits persistMiceTomography studyVivo evidenceEnvelope glycoproteinPLWHNeuroinflammation
2021
Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudyParanoia and belief updating during the COVID-19 crisis
Suthaharan P, Reed EJ, Leptourgos P, Kenney JG, Uddenberg S, Mathys CD, Litman L, Robinson J, Moss AJ, Taylor JR, Groman SM, Corlett PR. Paranoia and belief updating during the COVID-19 crisis. Nature Human Behaviour 2021, 5: 1190-1202. PMID: 34316049, PMCID: PMC8458246, DOI: 10.1038/s41562-021-01176-8.Peer-Reviewed Original ResearchConceptsTask behavior
2020
Introducing the PLOS ONE Collection on the neuroscience of reward and decision making
Groman SM, Ikemoto S, Rushworth M, Taylor JR, Whelan R. Introducing the PLOS ONE Collection on the neuroscience of reward and decision making. PLOS ONE 2020, 15: e0240505. PMID: 33031482, PMCID: PMC7544023, DOI: 10.1371/journal.pone.0240505.Peer-Reviewed Original ResearchConceptsAction-outcome associationsDecision-making deficitsPast experienceDecision makingNeuroscience techniquesNeurobiological mechanismsBehavioral approachNovel inferencesAdaptive decisionDecision-making functionsMechanistic linkParticular actionNeuroscienceAlternative outcomesBiological mechanismsOrganismsComputational functionsRewardNew insightsParticular outcomeNew environmentRecent advancesPredatorsMakingBiologyReinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30AdulthoodParanoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarmThe Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals
Groman SM. The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals. Current Topics In Behavioral Neurosciences 2020, 47: 23-52. PMID: 32157666, DOI: 10.1007/7854_2020_127.Peer-Reviewed Original ResearchConceptsImpulsive choiceNonhuman animalsReinforcement learning processSophisticated behavioralImpulsive decisionNeural mechanismsNeuroscience techniquesNeurobiological mechanismsNeuromodulatory systemsBehavioral heterogeneityApplication of reinforcementLearning processNeurochemical basisMental illnessIntegration of reinforcementImpulsivityPathological levels
2017
Model-Based Control in Dimensional Psychiatry
Voon V, Reiter A, Sebold M, Groman S. Model-Based Control in Dimensional Psychiatry. Biological Psychiatry 2017, 82: 391-400. PMID: 28599832, DOI: 10.1016/j.biopsych.2017.04.006.Peer-Reviewed Original ResearchExplaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience
Feeney EJ, Groman SM, Taylor JR, Corlett PR. Explaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience. Schizophrenia Bulletin 2017, 43: 263-272. PMID: 28177090, PMCID: PMC5605246, DOI: 10.1093/schbul/sbw194.Peer-Reviewed Original ResearchConceptsAssociative learning theoryPersistence of delusionsAttentional allocationCognitive psychologySet of beliefsAnimal beliefsNew learningComputational neuroscienceLearning theoryHuman beliefsErroneous beliefsBelief characteristicsBrain functionConsensual realityClinical phenomenologyAnimal researchBeliefsDelusionsComputational modelPsychotic illnessPsychologyPharmacological treatmentNeuroscienceTeleological approachFuture state
2014
Dissecting impulsivity and its relationships to drug addictions
Jentsch JD, Ashenhurst JR, Cervantes MC, Groman SM, James AS, Pennington ZT. Dissecting impulsivity and its relationships to drug addictions. Annals Of The New York Academy Of Sciences 2014, 1327: 1-26. PMID: 24654857, PMCID: PMC4360991, DOI: 10.1111/nyas.12388.Peer-Reviewed Original Research
2013
Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates
Groman SM, Jentsch JD. Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates. Current Opinion In Neurobiology 2013, 23: 625-631. PMID: 23528268, PMCID: PMC3731407, DOI: 10.1016/j.conb.2013.03.001.Peer-Reviewed Original ResearchConceptsNon-human primatesSerotonin systemStimulant-dependent individualsAddiction-related behaviorsInhibitory control deficitsTreatment of addictionDopamine systemNeural alterationsAddiction liabilityNovel targetStimulant useStimulant addictionFunctional phenotypeControl deficitsHuman primatesRecent dataInhibitory controlAddictionBi-directional relationshipBiological phenotypesPrimatesPhenotypeDiminished neurokinin‐1 receptor availability in patients with two forms of chronic visceral pain
Jarcho JM, Feier NA, Bert A, Labus JA, Lee M, Stains J, Ebrat B, Groman SM, Tillisch K, Brody AL, London ED, Mandelkern MA, Mayer EA. Diminished neurokinin‐1 receptor availability in patients with two forms of chronic visceral pain. Pain 2013, 154: 987-996. PMID: 23582152, PMCID: PMC4294187, DOI: 10.1016/j.pain.2013.02.026.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIrritable bowel syndromePositron emission tomographyClinical parametersPatient populationHealthy controlsIBS patientsChronic painInjury-related chronic painChronic visceral painNK-1R signalingPeripheral substance PChronic abdominal painPotential pharmacological interventionsIBD patientsVisceral painAbdominal painCentral sensitizationBowel syndromeBowel diseaseSubstance PPharmacological interventionsBrain expressionPatientsReceptor availability
2012
An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans
Dean AC, Groman SM, Morales AM, London ED. An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans. Neuropsychopharmacology 2012, 38: 259-274. PMID: 22948978, PMCID: PMC3527116, DOI: 10.1038/npp.2012.179.Peer-Reviewed Original ResearchConceptsCognitive declineCognitive difficultiesMA abuseLine of researchCognitive functionCognitive deficitsModerator variablesMiddle adulthoodCross-sectional human studiesBrain structuresTwin studiesAbuseIllicit substancesMethamphetamine abuseAbstinenceCognitionMethamphetamineIndividualsCausal relationshipDifficultiesRelationshipHuman studiesDeficitsFindingsAdulthood
2011
Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction
Groman SM, Jentsch JD. Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction. Depression And Anxiety 2011, 29: 295-306. PMID: 22147558, DOI: 10.1002/da.20897.Peer-Reviewed Original ResearchConceptsCognitive controlCognitive control abilitiesSubstantial psychosocial impairmentCognitive processesPsychosocial impairmentDimensional understandingCognitive dysfunctionControl abilityCategorical diagnosesPsychiatric conditionsParticular dimensionAddictionPsychiatric disordersImpairmentDisordersDA receptor functionPoint of convergenceCrucial dimensionDimensional natureReceptor transmissionDopamine D2-like receptorsFeelingsSymptomatologyTreatment responseD2-like receptors
2008
Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder
Groman SM, James AS, Jentsch JD. Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder. Neuroscience & Biobehavioral Reviews 2008, 33: 690-698. PMID: 18789354, PMCID: PMC2728075, DOI: 10.1016/j.neubiorev.2008.08.008.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderSubstance abuseSubstance abuse/dependenceHyperactivity disorderAnimal model studiesAbuse/dependenceAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderResponse inhibition functionDeficit hyperactivity disorderUltimate progressionDependence disordersUnderlying biological mechanismsAnimal modelsBehavioral impairmentsCingulate cortexDisordersMultiple causesExhibit deficitsADHD-like traitsDrug takingResponse inhibitionBiological mechanismsImpairmentNeural level