2013
Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus
Castorina A, D’Amico A, Scuderi S, Leggio G, Drago F, D’Agata V. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience 2013, 250: 546-556. PMID: 23906635, DOI: 10.1016/j.neuroscience.2013.07.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDopamine and cAMP-Regulated Phosphoprotein 32FibrinolysinGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHippocampusImmunohistochemistryLearningMaleMemoryMiceMice, KnockoutOncogene Protein v-aktPhosphorylationPrefrontal CortexReal-Time Polymerase Chain ReactionReceptors, Dopamine D3RNA, MessengerRNA, Ribosomal, 18STissue Plasminogen Activator
2012
Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells
Castorina A, Giunta S, Scuderi S, D’Agata V. Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells. Journal Of Molecular Neuroscience 2012, 48: 674-683. PMID: 22454142, DOI: 10.1007/s12031-012-9755-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCulture Media, Serum-FreeDNA ReplicationDNA, NeoplasmDose-Response Relationship, DrugGene Expression Regulation, NeoplasticHydrogen PeroxideNeoplasm ProteinsNerve Sheath NeoplasmsNerve Tissue ProteinsPituitary Adenylate Cyclase-Activating PolypeptideRatsReal-Time Polymerase Chain ReactionReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISignal TransductionTumor Cells, CulturedConceptsMalignant peripheral nerve sheath tumorActivity-dependent neuroprotective proteinMPNST cellsNormal serumSS cellsADNP expressionMalignant peripheral nerve sheath tumor cellsPeripheral nerve sheath tumorsNerve sheath tumorsCyclase-activating polypeptideVPAC receptor antagonistSheath tumorsReceptor antagonistNeuroprotective proteinTumor cellsSerum starvationMetabolic stressCaspase-3DeathCell viabilityDNA fragmentationInvolvementCell resistanceCellsSurvival response