2015
Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet
Musumeci G, Castrogiovanni P, Castorina S, Imbesi R, Szychlinska M, Scuderi S, Loreto C, Giunta S. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain Research Bulletin 2015, 119: 12-18. PMID: 26444078, DOI: 10.1016/j.brainresbull.2015.09.010.Peer-Reviewed Original ResearchConceptsFrontal cortexHigh TrP dietDentate gyrusTrp dietBrain areasBrain-derived neurotrophic factor (BDNF) expressionBrain-derived neurotrophic factorHigh-tryptophan dietNeuroplasticity-related moleculesBDNF protein expressionNeurotrophic factor expressionHippocampal region CA1Normal aging processAge-related cognitive declineChronic dietDiet protectsTryptophan dietWestern blot analysisBDNF expressionBDNF increaseBDNF systemNeurotrophin levelsAge-related declineTrp intakeNeurotrophic factorDifferent Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes
Scuderi S, D’amico A, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D’Agata V. Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes. Journal Of Molecular Neuroscience 2015, 56: 431-439. PMID: 25676032, DOI: 10.1007/s12031-015-0505-x.Peer-Reviewed Original ResearchConceptsIL-1 family membersDiabetic retinopathyIL-1αRetinal layersIL-1raIL-1βIL-1RIInvolvement of inflammationGanglion cell layerNew pharmacological approachesRetinal expression patternType 1 diabetesEffects of hyperglycemiaReceptor IL-1RIFamily membersCommon complicationDiabetic patientsDiabetic ratsProinflammatory cytokinesInflammatory processInterleukin-1βIntraperitoneal injectionRat modelInner plexiformIL-1RII
2014
Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death
Scuderi S, D’Amico A, Castorina A, Federico C, Marrazzo G, Drago F, Bucolo C, D’Agata V. Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. Journal Of Molecular Neuroscience 2014, 54: 395-404. PMID: 24488575, DOI: 10.1007/s12031-014-0244-4.Peer-Reviewed Original ResearchConceptsNAP treatmentRetinas of STZSingle intraocular injectionCaspase-3 expression levelsRetinal degenerative diseasesMAPK/ERK pathwayPhosphatidylinositol-3-kinase/Akt pathwayMitogen-activated protein kinase/extracellular signal-regulated protein kinaseDiabetes inductionDiabetic injuryDiabetic retinaSTZ injectionNeuroprotective effectsDiabetic modelIntraocular injectionPotent neuroprotectionDiabetic retinopathyVivo streptozotocinRetinal expressionProtein kinase/extracellular signal-regulated protein kinaseAmino acid peptideKinase/Akt pathwayP-AktP-ERKApoptosis markers