2023
Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity
Higerd-Rusli G, Tyagi S, Baker C, Liu S, Dib-Hajj F, Dib-Hajj S, Waxman S. Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2215417120. PMID: 36897973, PMCID: PMC10089179, DOI: 10.1073/pnas.2215417120.Peer-Reviewed Original ResearchConceptsCell biological mechanismsAxonal surfaceLive-cell imagingIon channel traffickingAnterograde transport vesiclesTransport vesiclesInflammatory mediatorsChannel traffickingPlasma membraneVesicular loadingIon channelsKv channelsPotential therapeutic targetPotassium channel KSodium channel NaTraffickingBiological mechanismsTherapeutic targetAbundanceRetrograde transportDistal axonsChannel NaInflammatory painNociceptor activityAxonal transport
2019
A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating
Tyagi S, Bendrick TR, Filipova D, Papadopoulos S, Bannister RA. A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating. The Journal Of General Physiology 2019, 151: 850-859. PMID: 31015257, PMCID: PMC6571999, DOI: 10.1085/jgp.201812237.Peer-Reviewed Original Research