2024
Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage
Rodríguez J, Uche O, Gao S, Lee S, Airola M, Bahmanyar S. Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage. Molecular Biology Of The Cell 2024, 35: ar101. PMID: 38776127, PMCID: PMC11244170, DOI: 10.1091/mbc.e23-09-0382.Peer-Reviewed Original ResearchLipin-1Lipid synthesisPhosphatase 1Lipid storageLipid dropletsLipid droplet biogenesisER enzymeER sizeER expansionCellular demandAmphipathic helixSynthesis of glycerophospholipidsProteasomal degradationRegulatory subunitMammalian cellsMembrane expansionN-terminusBinding interfaceLipid intermediatesNuclear envelopeMembrane synthesisLipidMetabolic conditionsBiogenesisLipin
2023
A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
Lee S, Rodrı́guez J, Merta H, Bahmanyar S. A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope. Journal Of Cell Biology 2023, 222: e202304026. PMID: 37382667, PMCID: PMC10309186, DOI: 10.1083/jcb.202304026.Peer-Reviewed Original ResearchConceptsAmphipathic helixDirect lipid-protein interactionsNuclear envelopeLipid-protein interactionsLipid compositionPhosphatidic acid phosphatase lipin-1INM proteomeNucleoplasmic domainOrganelle identityProteasomal regulationMembrane domainsAnimal cellsProteasomal degradationMaster regulatorProtein degradationLipid environmentLipin-1Packing defectsDAG speciesCTDNEP1Metabolism impactsSUN2Disease mechanismsMetabolismBroad implications