2024
Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage
Rodríguez J, Uche O, Gao S, Lee S, Airola M, Bahmanyar S. Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage. Molecular Biology Of The Cell 2024, 35: ar101. PMID: 38776127, PMCID: PMC11244170, DOI: 10.1091/mbc.e23-09-0382.Peer-Reviewed Original ResearchLipin-1Lipid synthesisPhosphatase 1Lipid storageLipid dropletsLipid droplet biogenesisER enzymeER sizeER expansionCellular demandAmphipathic helixSynthesis of glycerophospholipidsProteasomal degradationRegulatory subunitMammalian cellsMembrane expansionN-terminusBinding interfaceLipid intermediatesNuclear envelopeMembrane synthesisLipidMetabolic conditionsBiogenesisLipin
2022
Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth
Mauro MS, Celma G, Zimyanin V, Magaj MM, Gibson KH, Redemann S, Bahmanyar S. Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth. ELife 2022, 11: e75513. PMID: 35852146, PMCID: PMC9296133, DOI: 10.7554/elife.75513.Peer-Reviewed Original ResearchConceptsNuclear pore complexNPC assemblyMembrane biogenesisNE formationNPC densityNuclear pore complex assemblyEndoplasmic reticulumPore complex assemblyNuclear growthPore complexNDC1Redundant rolesComplex assemblyNPC numberBiogenesisMembrane incorporationFast turnoverNuclear formationBilayer lipidsNup53Membrane synthesisFirst divisionAssemblyGrowthNup160