2024
The evolutionary origins and ancestral features of septins
Delic S, Shuman B, Lee S, Bahmanyar S, Momany M, Onishi M. The evolutionary origins and ancestral features of septins. Frontiers In Cell And Developmental Biology 2024, 12: 1406966. PMID: 38994454, PMCID: PMC11238149, DOI: 10.3389/fcell.2024.1406966.Peer-Reviewed Original ResearchArginine fingerAncestral featuresEvolutionary originAncestral-sequence reconstructionChlorophyte green algaeFunction of septinsEukaryotic common ancestorGroups of orthologsCoiled-coil domainDiverse molecular functionsGuanine-nucleotide binding proteinsGlaucophyte algaeNon-opisthokontsGTPase domainDuplication eventsPhylogenetic relationshipsAncestral functionOrganelle fissionPhylogenetic treeAncestral traitCiliate speciesPhylogenetic groupsInteraction motifsAmphipathic helixCommon ancestorDifferential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage
Rodríguez J, Uche O, Gao S, Lee S, Airola M, Bahmanyar S. Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage. Molecular Biology Of The Cell 2024, 35: ar101. PMID: 38776127, PMCID: PMC11244170, DOI: 10.1091/mbc.e23-09-0382.Peer-Reviewed Original ResearchLipin-1Lipid synthesisPhosphatase 1Lipid storageLipid dropletsLipid droplet biogenesisER enzymeER sizeER expansionCellular demandAmphipathic helixSynthesis of glycerophospholipidsProteasomal degradationRegulatory subunitMammalian cellsMembrane expansionN-terminusBinding interfaceLipid intermediatesNuclear envelopeMembrane synthesisLipidMetabolic conditionsBiogenesisLipin
2023
A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
Lee S, Rodrı́guez J, Merta H, Bahmanyar S. A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope. Journal Of Cell Biology 2023, 222: e202304026. PMID: 37382667, PMCID: PMC10309186, DOI: 10.1083/jcb.202304026.Peer-Reviewed Original ResearchConceptsAmphipathic helixDirect lipid-protein interactionsNuclear envelopeLipid-protein interactionsLipid compositionPhosphatidic acid phosphatase lipin-1INM proteomeNucleoplasmic domainOrganelle identityProteasomal regulationMembrane domainsAnimal cellsProteasomal degradationMaster regulatorProtein degradationLipid environmentLipin-1Packing defectsDAG speciesCTDNEP1Metabolism impactsSUN2Disease mechanismsMetabolismBroad implications