2024
Efficient evolution of human antibodies from general protein language models.
Hie BL, Shanker VR, Xu D, Bruun TUJ, Weidenbacher PA, Tang S, Wu W, Pak JE, Kim PS. Efficient evolution of human antibodies from general protein language models. Nat Biotechnol 2024, 42: 275-283. PMID: 37095349, DOI: 10.1038/s41587-023-01763-2.Peer-Reviewed Original ResearchVaccine design via antigen reorientation.
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS. Vaccine design via antigen reorientation. Nat Chem Biol 2024 PMID: 38225471, DOI: 10.1038/s41589-023-01529-6.Peer-Reviewed Original Research
2023
Mitochondrial uncouplers impair human sperm motility without altering ATP content†.
Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, Lishko PV. Mitochondrial uncouplers impair human sperm motility without altering ATP content†. Biol Reprod 2023, 109: 192-203. PMID: 37294625, DOI: 10.1093/biolre/ioad064.Peer-Reviewed Original ResearchA structural blueprint for interleukin-21 signal modulation.
Abhiraman GC, Bruun TUJ, Caveney NA, Su LL, Saxton RA, Yin Q, Tang S, Davis MM, Jude KM, Garcia KC. A structural blueprint for interleukin-21 signal modulation. Cell Rep 2023, 42: 112657. PMID: 37339051, DOI: 10.1016/j.celrep.2023.112657.Peer-Reviewed Original ResearchA ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates.
Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, Hanson C, Joshi SB, Volkin DB, Pulendran B, Kim PS. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat Commun 2023, 14: 2149. PMID: 37069151, DOI: 10.1038/s41467-023-37417-9.Peer-Reviewed Original ResearchStructure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies.
Bruun TUJ, Tang S, Erwin G, Deis L, Fernandez D, Kim PS. Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies. J Biol Chem 2023, 299: 103062. PMID: 36841484, DOI: 10.1016/j.jbc.2023.103062.Peer-Reviewed Original Research1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction.
Lu Y, Shimada K, Tang S, Zhang J, Ogawa Y, Noda T, Shibuya H, Ikawa M. 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction. Proc Natl Acad Sci U S A 2023, 120: e2207263120. PMID: 36787362, DOI: 10.1073/pnas.2207263120.Peer-Reviewed Original ResearchSimplified Purification of Glycoprotein-Modified Ferritin Nanoparticles for Vaccine Development.
Weidenbacher P, Musunuri S, Powell AE, Tang S, Do J, Sanyal M, Kim PS. Simplified Purification of Glycoprotein-Modified Ferritin Nanoparticles for Vaccine Development. Biochemistry 2023, 62: 292-299. PMID: 35960597, DOI: 10.1021/acs.biochem.2c00241.Peer-Reviewed Original Research
2022
Human sperm TMEM95 binds eggs and facilitates membrane fusion.
Tang S, Lu Y, Skinner WM, Sanyal M, Lishko PV, Ikawa M, Kim PS. Human sperm TMEM95 binds eggs and facilitates membrane fusion. Proc Natl Acad Sci U S A 2022, 119: e2207805119. PMID: 36161911, DOI: 10.1073/pnas.2207805119.Peer-Reviewed Original Research
2021
Design principles of the ESCRT-III Vps24-Vps2 module.
Banjade S, Shah YH, Tang S, Emr SD. Design principles of the ESCRT-III Vps24-Vps2 module. Elife 2021, 10 PMID: 34028356, DOI: 10.7554/eLife.67709.Peer-Reviewed Original ResearchA Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice.
Powell AE, Zhang K, Sanyal M, Tang S, Weidenbacher PA, Li S, Pham TD, Pak JE, Chiu W, Kim PS. A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice. ACS Cent Sci 2021, 7: 183-199. PMID: 33527087, DOI: 10.1021/acscentsci.0c01405.Peer-Reviewed Original Research
2019
A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Tang S, Kim PS. A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc Natl Acad Sci U S A 2019, 116: 24500-24506. PMID: 31727844, DOI: 10.1073/pnas.1916916116.Peer-Reviewed Original ResearchElectrostatic lateral interactions drive ESCRT-III heteropolymer assembly.
Banjade S, Tang S, Shah YH, Emr SD. Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly. Elife 2019, 8 PMID: 31246173, DOI: 10.7554/eLife.46207.Peer-Reviewed Original ResearchGenetic and Biochemical Analyses of Yeast ESCRT.
Banjade S, Tang S, Emr SD. Genetic and Biochemical Analyses of Yeast ESCRT. Methods Mol Biol 2019, 1998: 105-116. PMID: 31250297, DOI: 10.1007/978-1-4939-9492-2_8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2017
Cap-dependent translational control of oncolytic measles virus infection in malignant mesothelioma.
Jacobson BA, Sadiq AA, Tang S, Jay-Dixon J, Patel MR, Drees J, Sorenson BS, Russell SJ, Kratzke RA. Cap-dependent translational control of oncolytic measles virus infection in malignant mesothelioma. Oncotarget 2017, 8: 63096-63109. PMID: 28968974, DOI: 10.18632/oncotarget.18656.Peer-Reviewed Original Research
2016
ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis.
Tang S, Buchkovich NJ, Henne WM, Banjade S, Kim YJ, Emr SD. ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis. Elife 2016, 5 PMID: 27074665, DOI: 10.7554/eLife.15507.Peer-Reviewed Original Research
2015
Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments.
Tang S, Henne WM, Borbat PP, Buchkovich NJ, Freed JH, Mao Y, Fromme JC, Emr SD. Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments. Elife 2015, 4 PMID: 26670543, DOI: 10.7554/eLife.12548.Peer-Reviewed Original ResearchVesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer.
Patel MR, Jacobson BA, Ji Y, Drees J, Tang S, Xiong K, Wang H, Prigge JE, Dash AS, Kratzke AK, Mesev E, Etchison R, Federspiel MJ, Russell SJ, Kratzke RA. Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget 2015, 6: 33165-77. PMID: 26431376, DOI: 10.18632/oncotarget.5320.Peer-Reviewed Original ResearchEfficient assembly of oligomannosides using the hydrophobically assisted switching phase method.
Meng S, Tian T, Han D, Wang LN, Tang SG, Meng XB, Li ZJ. Efficient assembly of oligomannosides using the hydrophobically assisted switching phase method. Org Biomol Chem 2015, 13: 6711-22. PMID: 25967589, DOI: 10.1039/c5ob00730e.Peer-Reviewed Original ResearchTriptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma.
Jacobson BA, Chen EZ, Tang S, Belgum HS, McCauley JA, Evenson KA, Etchison RG, Jay-Dixon J, Patel MR, Raza A, Saluja AK, D'Cunha J, Kratzke RA. Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma. Genes Cancer 2015, 6: 144-52. PMID: 26000097, DOI: 10.18632/genesandcancer.55.Peer-Reviewed Original Research