2018
Cardiomyocyte-specific deletion of GSK-3β leads to cardiac dysfunction in a diet induced obesity model
Gupte M, Tumuluru S, Sui JY, Singh AP, Umbarkar P, Parikh SS, Ahmad F, Zhang Q, Force T, Lal H. Cardiomyocyte-specific deletion of GSK-3β leads to cardiac dysfunction in a diet induced obesity model. International Journal Of Cardiology 2018, 259: 145-152. PMID: 29398139, PMCID: PMC5869114, DOI: 10.1016/j.ijcard.2018.01.013.Peer-Reviewed Original ResearchConceptsHigh-fat dietAdverse ventricular remodelingCardiac dysfunctionCardiac functionVentricular remodelingBody weightGSK-3βControl dietHeart weight/tibia lengthDiet-induced cardiac dysfunctionIndependent risk factorImpaired cardiac functionSevere cardiac dysfunctionFat mass compositionLittermate control miceProtective compensatory mechanismCardiomyocyte-specific deletionComparable body weightTibia lengthTransthoracic echocardiographyControl miceObesity modelRisk factorsMyocardial diseaseDysfunction
2014
Troponin I-Interacting Protein Kinase
Lal H, Ahmad F, Parikh S, Force T. Troponin I-Interacting Protein Kinase. Circulation Journal 2014, 78: 1514. PMID: 24899531, PMCID: PMC4151348, DOI: 10.1253/circj.cj-14-0543.Peer-Reviewed Original ResearchConceptsIR injuryMyocardial infarctionCardiomyocyte deathNew drug targetsNovel genetic animal modelsEffective myocardial reperfusionAcute coronary syndromeIschemia-reperfusion injuryPercutaneous coronary interventionCoronary artery diseaseCause of deathProfound oxidative stressPromising new drug targetGenetic animal modelsCardiac troponin ITNNI3KDrug targetsCoronary syndromeCoronary interventionArtery diseaseMyocardial reperfusionReperfusion injuryCardiac dysfunctionIschemic injuryInfarct size