2007
An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis
Ranjbaran H, Sokol SI, Gallo A, Eid RE, Iakimov AO, D’Alessio A, Kapoor JR, Akhtar S, Howes CJ, Aslan M, Pfau S, Pober JS, Tellides G. An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis. The Journal Of Immunology 2007, 178: 592-604. PMID: 17182600, DOI: 10.4049/jimmunol.178.1.592.Peer-Reviewed Original ResearchConceptsIL-12/ILIFN-gamma-inducible chemokinesCoronary atherosclerosisIL-12IL-18IFN-gammaPlasma levelsT cellsTh1-type cytokine productionHuman atherosclerotic coronary arteriesAcute coronary syndromeSubset of patientsHuman coronary atherosclerosisTh1-type cytokinesC-reactive proteinIFN-γ productionElevated plasma levelsPlasma of patientsInnate immune responseAtherosclerotic coronary arteriesCoronary syndromeSystemic inflammationCardiac catheterizationCardiopulmonary bypassGamma secretion
2006
Heparin Displaces Interferon-γ–Inducible Chemokines (IP-10, I-TAC, and Mig) Sequestered in the Vasculature and Inhibits the Transendothelial Migration and Arterial Recruitment of T Cells
Ranjbaran H, Wang Y, Manes TD, Yakimov AO, Akhtar S, Kluger MS, Pober JS, Tellides G. Heparin Displaces Interferon-γ–Inducible Chemokines (IP-10, I-TAC, and Mig) Sequestered in the Vasculature and Inhibits the Transendothelial Migration and Arterial Recruitment of T Cells. Circulation 2006, 114: 1293-1300. PMID: 16940188, DOI: 10.1161/circulationaha.106.631457.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory AgentsCell MovementCells, CulturedChemokine CXCL10Chemokine CXCL11Chemokine CXCL9ChemokinesChemokines, CXCCoronary Artery DiseaseCoronary VesselsEndothelium, VascularHeparinHeparin AntagonistsHumansInterferon-gammaInterleukin-12ProtaminesProtein BindingReceptors, ChemokineReceptors, CXCR3Th1 CellsT-LymphocytesConceptsIP-10Heparin administrationCoronary arteryEndothelial cellsI-TACT cellsIFN-gamma-dependent productionTh1-type inflammatory diseasesI-TAC/CXCL11IP-10/CXCL10IFN-gamma-producing Th1 cellsTransendothelial migrationInflammatory arterial diseaseNonanticoagulant heparin derivativesCoronary artery bypassChemokines IP-10/CXCL10Memory T cellsT helper cellsMIG/CXCL9IFN-gamma responsesEffect of heparinAtherosclerotic coronary arteriesHuman coronary arteriesImmunodeficient mouse hostsCultured endothelial cells