2022
Inhibitory Effect of Biotransformed-Fucoidan on the Differentiation of Osteoclasts Induced by Receptor for Activation of Nuclear Factor-κB Ligand
Park B, Yu S, Kim S, Lee J, Choi S, Chang J, Yang E, Kim K, Ahn S. Inhibitory Effect of Biotransformed-Fucoidan on the Differentiation of Osteoclasts Induced by Receptor for Activation of Nuclear Factor-κB Ligand. Journal Of Microbiology And Biotechnology 2022, 32: 1017-1025. PMID: 35879294, PMCID: PMC9628933, DOI: 10.4014/jmb.2203.03001.Peer-Reviewed Original ResearchConceptsNuclear factor-κB ligandBone marrow macrophagesOsteoclast differentiationBone homeostasisBackground of osteoporosisLow molecular weight fucoidanExpression of NFATc1Effect of fucoidanDifferentiation of osteoclastsResistant acid phosphatase activityHarmful side effectsSide effectsPharmaceutical treatmentWeight fucoidanKey transcriptional factorOsteoporosisMarrow macrophagesDifferentiated osteoclastsInhibitory effectOsteoclastsRT-PCRC-fosSafe natural product
2021
Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation
Koo JH, Kim SH, Jeon SH, Kang MJ, Choi JM. Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation. Biomaterials 2021, 274: 120845. PMID: 33971559, DOI: 10.1016/j.biomaterials.2021.120845.Peer-Reviewed Original ResearchMeSH KeywordsHumansInflammasomesLeucineLipopolysaccharidesMacrophagesMitochondrial ProteinsNF-kappa BSepsisConceptsSystemic inflammationSepsis modelNF-κBAcute systemic inflammatory diseaseSymptoms of sepsisSystemic inflammatory diseaseAnti-TNFα antibodyIL-6 productionIL-1β productionEffective therapeutic agentCaspase-1 activationOrgan dysfunctionLethal sepsisTreatment optionsInflammatory diseasesP65 phosphorylationSepsisIκB degradationBacterial infectionsPeritoneal macrophagesTherapeutic agentsMacrophagesInflammationInflammasomeLPS