2024
Exploring a Novel Role of Glycerol Kinase 1 in Prostate Cancer PC-3 Cells
Park B, Kim S, Yu S, Kim K, Jeon H, Ahn S. Exploring a Novel Role of Glycerol Kinase 1 in Prostate Cancer PC-3 Cells. Biomolecules 2024, 14: 997. PMID: 39199385, PMCID: PMC11352368, DOI: 10.3390/biom14080997.Peer-Reviewed Original ResearchPC-3 cellsProstate cancer PC-3 cellsGK deficiencyCell deathProstate cancerAnti-cancer agentsKinase 1Apoptotic cell deathDNA microarray analysisHuman prostate cancer PC-3 cellsCancer cell deathModulating tumor microenvironmentProstate cancer cellsBiomarkers of cell deathX chromosomeReduced cell viabilityEpigenetic regulationExpression vectorInvestigated genesSynthesis of triglyceridesMicroarray analysisGenetic alterationsTumor microenvironmentNovel roleCancer cells
2020
Dual role of reactive oxygen species in autophagy and apoptosis induced by compound PN in prostate cancer cells
Choi H, Kim K, Park K, Kim S, Park S, Yu S, Kim Y, Kim D, Chung K, Ahn S. Dual role of reactive oxygen species in autophagy and apoptosis induced by compound PN in prostate cancer cells. Molecular & Cellular Toxicology 2020, 17: 41-50. DOI: 10.1007/s13273-020-00107-4.Peer-Reviewed Original ResearchMitochondrial reactive oxygen speciesReactive oxygen speciesCell deathMolecular mechanismsProstate cancer cellsPC-3 cellsCell survivalAnti-cancer activityROS productionApoptotic cell deathCancer cellsOxygen speciesROS-dependent mannerInduction of apoptosisProstate cancer PC-3 cellsHuman prostate cancer cellsAcceleration of apoptosisCancer PC-3 cellsInhibition of autophagyProduction of intracellularIntracellular ROS scavengerProstate cancer treatmentExpression of apoptosisAutophagy inductionWestern blot analysis
2017
Salinomycin induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells
Yu S, Kim S, Kim K, Ji J, Seo Y, Yu H, Ahn S. Salinomycin induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells. Oncology Reports 2017, 37: 3321-3328. PMID: 28498472, DOI: 10.3892/or.2017.5615.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesER stressHuman glioma U87MG cellsEndoplasmic reticulumGlioma U87MG cellsU87MG cellsStress-related proteinsAcidic vesicular organellesOxygen speciesER stress-related proteinsHuman cancer cellsAutophagy marker proteinsVesicular organellesImpact of salinomycinEndoplasmic reticulum stress-mediated autophagyMolecular mechanismsCell deathAutophagyMarker proteinsAutophagy inhibitorCancer cell linesGlioma cancer cell linesInduced apoptosisROS scavengerExpression levels