2022
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Zhang M, Liu ZZ, Aoshima K, Cai WL, Sun H, Xu T, Zhang Y, An Y, Chen JF, Chan LH, Aoshima A, Lang SM, Tang Z, Che X, Li Y, Rutter SJ, Bossuyt V, Chen X, Morrow JS, Pusztai L, Rimm DL, Yin M, Yan Q. CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression. Science Translational Medicine 2022, 14: eabf5473. PMID: 35108062, PMCID: PMC9003667, DOI: 10.1126/scitranslmed.abf5473.Peer-Reviewed Original ResearchConceptsBreast cancer metastasisReticuloendotheliosis viral oncogene homolog ACancer metastasisImmune suppressionM2 macrophagesWorse metastasis-free survivalMetastatic breast cancerMetastasis-free survivalV-rel avian reticuloendotheliosis viral oncogene homolog ACancer-related deathPrimary breast tumorsMultiple mouse modelsNF-κB signalingImmunocompetent settingNuclear factor-κB family membersMetastasis-promoting genesDistant metastasisMetastatic sitesPrimary tumorEffective therapyBreast cancerMetastasis treatmentMouse modelBreast tumorsMetastasis
2002
Die Expression der ζ-Kette des T-Zell-Rezeptors als Prognosemarker bei Kopf-Hals-Karzinomen
Müller D, Lang S, Roskrow M, Wollenberg B. Die Expression der ζ-Kette des T-Zell-Rezeptors als Prognosemarker bei Kopf-Hals-Karzinomen. Laryngo-Rhino-Otologie 2002, 81: 516-520. PMID: 12173063, DOI: 10.1055/s-2002-33289.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesZeta chain expressionPeripheral blood lymphocytesT cell receptorTumor stageZeta chainCorrelated to clinical dataMechanisms of immune suppressionT cell receptor zeta chainSystemic immune defectsAnti-tumor responsesEarly tumor stageHigher tumor stageSquamous cell carcinomaHead and neckT cell activationFlow cytometric analysisSystemic immunomodulationImmune defectsInfiltrating lymphocytesClinical aggressivenessCell carcinomaImmune suppressionBlood lymphocytesSCCHN