2019
Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer
Aggarwal C, Thompson J, Black T, Katz S, Fan R, Yee S, Chien A, Evans T, Bauml J, Alley E, Ciunci C, Berman A, Cohen R, Lieberman D, Majmundar K, Savitch S, Morrissette J, Hwang W, Elenitoba-Johnson K, Langer C, Carpenter E. Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer. JAMA Oncology 2019, 5: 173-180. PMID: 30325992, PMCID: PMC6396811, DOI: 10.1001/jamaoncol.2018.4305.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Non-Small-Cell LungClinical Decision-MakingDNA Mutational AnalysisFemaleGenetic Predisposition to DiseaseHumansLung NeoplasmsMaleMiddle AgedMutationPatient SelectionPhenotypePrecision MedicinePredictive Value of TestsPrognosisProspective StudiesConceptsNon-small cell lung cancerTissue next-generation sequencingMetastatic non-small cell lung cancerCell lung cancerTargetable mutationsNext-generation sequencingLung cancerPlasma testingStage IV non-small cell lung cancerAllele fractionNGS testingClinical implicationsPlasma next-generation sequencingPersonalized therapyReal-world clinical settingProspective cohort studyResponse Evaluation CriteriaRoutine clinical managementNumber of patientsSolid Tumors responseDNA next-generation sequencingStable diseaseMutation allele fractionCohort studyPartial response
2018
Measurement and immunophenotyping of pleural fluid EpCAM-positive cells and clusters for the management of non-small cell lung cancer patients
Thompson J, Fan R, Black T, Yu G, Savitch S, Chien A, Yee S, Sen M, Hwang W, Katz S, Feldman M, Vachani A, Carpenter E. Measurement and immunophenotyping of pleural fluid EpCAM-positive cells and clusters for the management of non-small cell lung cancer patients. Lung Cancer 2018, 127: 25-33. PMID: 30642547, PMCID: PMC6657687, DOI: 10.1016/j.lungcan.2018.11.020.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMalignant pleural effusionPleural fluid samplesEpCAM-positive cellsPD-L1 expressionNSCLC patientsOverall survivalPrognostic informationNon-small cell lung cancer patientsFluid samplesCell lung cancer patientsCox proportional hazards modelInferior overall survivalKaplan-Meier methodNon-malignant groupCell lung cancerLung cancer patientsProportional hazards modelPleural fluid specimensCommon complicationPD-L1Pleural effusionCurrent gold standardCancer patientsLung cancer