2023
Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2021
The feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses
Lydon‐Staley D, MacLean RR, Falk EB, Bassett DS, Wilson SJ. The feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses. Addiction Biology 2021, 26: e13001. PMID: 33508880, PMCID: PMC8225575, DOI: 10.1111/adb.13001.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFunctional brain systemsCognitive controlBrain systemsDefault mode systemLapse behaviorSmoking cessation attemptFrontoparietal systemNeural correlatesMonetary rewardsBehavioral paradigmsNeural activityInitial evidenceScanning sessionSmoking abstinenceCessation attemptsDaily smokersTime-varying changesSingle scanning sessionQuitting smokingBehavioral modelMagnetic resonance imagingAbstinenceParticipantsParadigm
2020
Naturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation
MacLean RR, Sofuoglu M, Waters AJ. Naturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation. Drug And Alcohol Dependence 2020, 209: 107892. PMID: 32058247, DOI: 10.1016/j.drugalcdep.2020.107892.Peer-Reviewed Original ResearchConceptsAlcohol attentional biasAttentional biasAlcohol cuesAmbulatory assessmentPossible cognitive mechanismsTask four timesHeavy drinking smokersCognitive mechanismsCue typesDrug cuesPreferential attentionNaturalistic measurementsCuesAlcohol useDaily smokersSubject associationsLarge sampleDaily lifeBiasFurther researchFirst studyPreliminary investigationCravingHeavy amountsCigarettes