2013
In vivo GABA T2 determination with J‐refocused echo time extension at 7 T
Andreychenko A, Klomp D, de Graaf R, Luijten P, Boer V. In vivo GABA T2 determination with J‐refocused echo time extension at 7 T. NMR In Biomedicine 2013, 26: 1596-1601. PMID: 23893556, DOI: 10.1002/nbm.2997.Peer-Reviewed Original ResearchMeSH KeywordsCreatineGamma-Aminobutyric AcidHumansMagnetic Resonance ImagingPhantoms, ImagingSignal Processing, Computer-AssistedTime FactorsConceptsCoupled spin systemsSpin systemsRelaxation timeEcho timeJ-coupled spinsT. A methodMultiple echo timesEdited signalSpectral editing techniquesShort echo timeT2 decay curvesT2 decayJ-couplingMEGA-sLASERTarget resonancesJ-modulationShape correctionEdited spectraDecay curvesResonanceT2 determinationT2 relaxation timesSpinSignal intensityDecay
2012
In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy
van der Hel W, van Eijsden P, Bos IW, de Graaf R, Behar KL, van Nieuwenhuizen O, de Graan P, Braun KP. In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy. NMR In Biomedicine 2012, 26: 132-140. PMID: 22806932, DOI: 10.1002/nbm.2828.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyStatus epilepticusSynthase immunoreactivityNeuronal lossHippocampal pathologyLobe epilepsyDevelopment of TLECholine-containing compound concentrationsChildhood status epilepticusPre-epileptic stateSpontaneous recurrent seizuresVivo MRSJuvenile rat modelHippocampal injuryChronic epilepsyRecurrent seizuresSpontaneous seizuresNeurotransmitter imbalanceParvalbumin immunoreactivityVivo immunohistochemistryInhibitory neurotransmissionΓ-aminobutyric acidEpileptogenic processMRS findingsNeuronal death
2009
In vivo neurochemical profiling of rat brain by 1H‐[13C] NMR spectroscopy: cerebral energetics and glutamatergic/GABAergic neurotransmission
Van Eijsden P, Behar KL, Mason GF, Braun KP, De Graaf RA. In vivo neurochemical profiling of rat brain by 1H‐[13C] NMR spectroscopy: cerebral energetics and glutamatergic/GABAergic neurotransmission. Journal Of Neurochemistry 2009, 112: 24-33. PMID: 19818103, PMCID: PMC2843425, DOI: 10.1111/j.1471-4159.2009.06428.x.Peer-Reviewed Original ResearchConceptsGABAergic neurotransmissionRat brainGlutamatergic/GABAergic neurotransmissionLow GABA concentrationsInhibitory neurotransmissionGlutamatergic neurotransmissionCerebral energeticsGABA concentrationNeurotransmissionBrain functionNeurotransmitter fluxEnergy metabolismNeurochemical profilingVivoBrainHigh magnetic fieldsGABAergicExcitatoryMagnetic field
2001
Detection of γ-Aminobutyric Acid (GABA) by Longitudinal Scalar Order Difference Editing
de Graaf R, Rothman D. Detection of γ-Aminobutyric Acid (GABA) by Longitudinal Scalar Order Difference Editing. Journal Of Magnetic Resonance 2001, 152: 124-131. PMID: 11531371, DOI: 10.1006/jmre.2001.2371.Peer-Reviewed Original Research