2021
Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer
Liu Q, Liu G, Martin DT, Xing YT, Weiss RM, Qi J, Kang J. Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer. Asian Journal Of Andrology 2021, 23: 472-478. PMID: 33762478, PMCID: PMC8451484, DOI: 10.4103/aja.aja_20_21.Peer-Reviewed Original ResearchConceptsDNA methylationRisk lociGene expressionGenome-wide association analysisExpression quantitative trait loci (eQTL) analysisQuantitative trait locus (QTL) analysisMethylation-regulated genesEpigenetic association studiesSingle nucleotide polymorphism analysisNucleotide polymorphism analysisTranscript regulationGenomic regionsCancer Genome AtlasEpigenetic changesEpigenetic alterationsLocus analysisAssociation studiesAssociation analysisProgression of tumorsCpG sitesGenesLociMethylationGenome AtlasImportant locusAchieving highly efficient gene transfer to the bladder by increasing the molecular weight of polymer-based nanoparticles
Li G, He S, Schätzlein AG, Weiss RM, Martin DT, Uchegbu IF. Achieving highly efficient gene transfer to the bladder by increasing the molecular weight of polymer-based nanoparticles. Journal Of Controlled Release 2021, 332: 210-224. PMID: 33607176, DOI: 10.1016/j.jconrel.2021.02.007.Peer-Reviewed Original ResearchDown-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis
He S, Li G, Schätzlein AG, Humphrey PA, Weiss RM, Uchegbu IF, Martin DT. Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis. Cellular Signalling 2021, 81: 109931. PMID: 33529758, DOI: 10.1016/j.cellsig.2021.109931.Peer-Reviewed Original ResearchConceptsBladder cancer cellsCancer cellsHuman bladder cancer specimensCisplatin-based chemotherapyBladder cancer treatmentBladder cancer specimensChemoresistant bladder cancer cellsBreast cancer cellsCell viabilityBladder cancerCancer specimensSmall molecule inhibitorsLevels of Ku70Cancer treatmentKu70 expression
2019
Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth
Li X, He S, Tian Y, Weiss RM, Martin DT. Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth. Cellular Signalling 2019, 63: 109381. PMID: 31374291, DOI: 10.1016/j.cellsig.2019.109381.Peer-Reviewed Original ResearchMeSH KeywordsButadienesCarcinoma, Transitional CellCell Line, TumorCell MovementCell SurvivalDrug Resistance, NeoplasmDrug SynergismEnzyme InhibitorsGene Expression Regulation, NeoplasticGlycoproteinsHumansHydrazinesMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1NitrilesQuinoxalinesUrinary Bladder NeoplasmsConceptsChemoresistant bladder cancerBladder cancer cellsBladder cancerInterleukin-6Clinical outcomesMultidrug resistanceGemcitabine-resistant bladder cancer cellsBladder cancer cell growthMajor treatment obstacleMetastatic bladder cancerPI3K/Akt/mTOR signalingCancer cellsResistant bladder cancer cellsPoor clinical outcomeAkt/mTOR SignalingSynergistic inhibitionNovel therapeutic strategiesPotential therapeutic targetMEK/ERK signalingCancer cell growthRaf/MEK/ERK signalingRole of gp130Therapeutic strategiesTreatment obstaclesTherapeutic targetGlycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target
Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM. Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target. Molecular Cancer Therapeutics 2019, 18: molcanther.1079.2017. PMID: 30381445, PMCID: PMC6363894, DOI: 10.1158/1535-7163.mct-17-1079.Peer-Reviewed Original ResearchConceptsBladder cancer cell linesBladder tumorsBladder cancerCancer cell linesHigh-grade bladder cancer cell linesCancer xenograft mouse modelBladder cancer growthAggressive bladder cancerPotential therapeutic targetHuman bladder tumorsXenograft mouse modelBladder cancer progressionCell linesBladder tumor cellsCurative potentialOptimal treatmentTumor gradePatient outcomesReduced cell migrationTumor volumeTumor categoryMouse modelTherapeutic targetTumor aggressivenessCancer growth
2018
Legends in Urology.
Weiss RM. Legends in Urology. The Canadian Journal Of Urology 2018, 25: 9296-9299. PMID: 29900814.Peer-Reviewed Original Research
2015
Blocking Glycoprotein‐130 Pathway Decreases Bladder Cancer Growth
Martin D, Steinbach J, Saltzman W, Weiss R. Blocking Glycoprotein‐130 Pathway Decreases Bladder Cancer Growth. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.889.11.Peer-Reviewed Original ResearchBacillus Calmette-GuerinExpression of gp130Bladder cancer cellsBladder cancerCancer specimensNon-muscle invasive bladder cancerCancer cellsEffective adjuvant agentInvasive bladder cancerWeeks of treatmentBladder cancer tissue microarrayBladder cancer growthComprehensive cancer centerBladder cancer specimensCancer tissue microarrayHuman bladder cancerAdjuvant agentBladder tumorsCancer CenterCytokeratin 20Signal transduction pathwaysCalmette-GuerinTumor gradeTissue microarrayCarcinoma markersMP49-10 KNOCKDOWN OF GLYCOPROTEIN-130 INHIBITS BLADDER CANCER PROGRESSION AND MIGRATION
Martin D, Steinbach J, Wheeler M, Nawaf C, Saltzman W, Weiss R. MP49-10 KNOCKDOWN OF GLYCOPROTEIN-130 INHIBITS BLADDER CANCER PROGRESSION AND MIGRATION. Journal Of Urology 2015, 193: e606. DOI: 10.1016/j.juro.2015.02.514.Peer-Reviewed Original Research
2014
Surface-Modified Nanoparticles Enhance Transurothelial Penetration and Delivery of Survivin siRNA in Treating Bladder Cancer
Martin DT, Steinbach JM, Liu J, Shimizu S, Kaimakliotis HZ, Wheeler MA, Hittelman AB, Saltzman W, Weiss RM. Surface-Modified Nanoparticles Enhance Transurothelial Penetration and Delivery of Survivin siRNA in Treating Bladder Cancer. Molecular Cancer Therapeutics 2014, 13: 71-81. PMID: 24222663, PMCID: PMC3924597, DOI: 10.1158/1535-7163.mct-13-0502.Peer-Reviewed Original ResearchConceptsBladder permeability barrierSurvivin siRNAChitosan delivery systemBladder cancerBladder diseaseTherapeutic responseTumor volumeXenograft tumorsMouse bladderTumor siteSurvivin expressionIntravesical deliveryHuman ureterTumor cell uptakeSiRNATumorsUnmodified nanoparticlesCell uptakeDelivery system
2013
Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer
Martin DT, Hoimes CJ, Kaimakliotis HZ, Cheng CJ, Zhang K, Liu J, Wheeler MA, Kelly WK, Tew GN, Saltzman WM, Weiss RM. Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. Nanomedicine Nanotechnology Biology And Medicine 2013, 9: 1124-1134. PMID: 23764660, PMCID: PMC3815967, DOI: 10.1016/j.nano.2013.05.017.Peer-Reviewed Original ResearchConceptsHistone deacetylase inhibitor belinostatBladder cancerBladder permeability barrierNon-invasive bladder cancerCultured bladder cancer cellsBladder cancer cellsChemotherapy efficacyIntravesical drug deliveryXenograft tumorsMouse bladderMouse modelConvincing dataHuman ureterBelinostatCancerCancer cellsLower IC50TumorsAcetyl-H4Tissue penetrationCLINICAL EDITORIntracellular uptakeDeliveryCellsPatientsA novel polymer-coated nanoparticle (NP) for urothelium penetration and drug delivery.
Hoimes C, Martin D, Kaimakliotis H, Cheng C, Kelly W, Tew G, Wheeler M, Weiss R, Saltzman W. A novel polymer-coated nanoparticle (NP) for urothelium penetration and drug delivery. Journal Of Clinical Oncology 2013, 31: e15543-e15543. DOI: 10.1200/jco.2013.31.15_suppl.e15543.Peer-Reviewed Original ResearchBladder cancerUM-UC-3Human ureterProgression of BCNon-invasive bladder cancerInhibition of invasionHDAC inhibitor belinostatFlank xenograftsTumor sizeDisease progressionTumor regressionUrothelial barrierTumor volumeIntravesical drug deliveryMouse bladderBC cellsHDAC inhibitionMurine bladderCell cytotoxicityT24 lineFACS analysisSimilar IC50Three daysFinal treatmentUreterBrg1 Determines Urothelial Cell Fate during Ureter Development
Weiss RM, Guo S, Shan A, Shi H, Romano RA, Sinha S, Cantley LG, Guo JK. Brg1 Determines Urothelial Cell Fate during Ureter Development. Journal Of The American Society Of Nephrology 2013, 24: 618-626. PMID: 23449535, PMCID: PMC3609140, DOI: 10.1681/asn.2012090902.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsUreter developmentBasal cell populationUreteral smooth muscle cellsHoxb7-CreTerminal differentiationPPARγ expressionUreteral epitheliumMuscle cellsUrothelial cellsP63 expressionRole of BRG1Basal cellsUmbrella cellsCell populationsSonic hedgehog expressionEpithelial stratificationAdult ureterUreterCell developmentBRG1 expressionSmooth muscle cell developmentShh expressionCellsHedgehog expression
2012
907 EFFECT OF INTRAVESICAL BOTULINUM TOXIN A DELIVERY (USING DMSO) IN RAT OVERACTIVE BLADDER MODEL
Shimizu S, Wheeler M, Saito M, Weiss R, Hittelman A. 907 EFFECT OF INTRAVESICAL BOTULINUM TOXIN A DELIVERY (USING DMSO) IN RAT OVERACTIVE BLADDER MODEL. Journal Of Urology 2012, 187: e370. DOI: 10.1016/j.juro.2012.02.1003.Peer-Reviewed Original Research
2011
MP-04.16 Uptake of Surface Modified Poly(Lactide-Co-Glycolide) Nanoparticles in Bladder Cancer Cells and in Human Ureter and Mouse Bladder
Weiss R, Martin D, Steinbach J, Liu J, Kaimakliotis H, Wheeler M, Hittelman A, Saltzman W. MP-04.16 Uptake of Surface Modified Poly(Lactide-Co-Glycolide) Nanoparticles in Bladder Cancer Cells and in Human Ureter and Mouse Bladder. Urology 2011, 78: s55. DOI: 10.1016/j.urology.2011.07.090.Peer-Reviewed Original Research1055 SURFACE MODIFICATIONS OF POLY(LACTIDE-CO-GLYCOLIDE) NANOPARTICLES CAN INCREASE ITS UPTAKE BY BLADDER CANCER CELLS
Martin D, Steinbach J, Kaimakliotis H, Liu J, Wheeler M, Hittelman A, Saltzman W, Weiss R. 1055 SURFACE MODIFICATIONS OF POLY(LACTIDE-CO-GLYCOLIDE) NANOPARTICLES CAN INCREASE ITS UPTAKE BY BLADDER CANCER CELLS. Journal Of Urology 2011, 185: e424. DOI: 10.1016/j.juro.2011.02.1092.Peer-Reviewed Original Research1358 NANOPARTICLE DELIVERY OF THE HISTONE DEACETYLASE INHIBITOR PXD101 FACILITATES BLADDER CANCER CELL UPTAKE AND CYTOTOXICITY
Kaimakliotis H, Martin D, Hoimes C, Cheng C, Liu J, Kelly K, Tew G, Saltzman W, Weiss R. 1358 NANOPARTICLE DELIVERY OF THE HISTONE DEACETYLASE INHIBITOR PXD101 FACILITATES BLADDER CANCER CELL UPTAKE AND CYTOTOXICITY. Journal Of Urology 2011, 185: e542. DOI: 10.1016/j.juro.2011.02.1180.Peer-Reviewed Original Research
2010
Effect of mitomycin C on concentrations of vascular endothelial growth factor and its receptors in bladder cancer cells and in bladders of rats intravesically instilled with mitomycin C
Verma A, DeGrado J, Hittelman AB, Wheeler MA, Kaimakliotis HZ, Weiss RM. Effect of mitomycin C on concentrations of vascular endothelial growth factor and its receptors in bladder cancer cells and in bladders of rats intravesically instilled with mitomycin C. BJU International 2010, 107: 1154-1161. PMID: 20735383, DOI: 10.1111/j.1464-410x.2010.09543.x.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorVascular endothelial growth factor receptor 2Bladder cancer cellsVEGF receptor 1Bladder of ratsEndothelial growth factorVEGFR-2 mRNAMitomycin CVEGFR-2 proteinCancer cellsSurvivin siRNAVEGF concentrationsMMC concentrationsUrinary vascular endothelial growth factorGrowth factorVEGFR-2 concentrationsGrowth factor receptor 2Superficial bladder cancerTransitional cell carcinomaMMC treatmentEndothelial growth factor receptor 2Factor receptor 2Interleukin-6 mRNAEffective intravesical treatmentLower MMC concentrations436 EFFECT OF SURVIVIN SIRNA AND VEGF SIRNA COMPLEXED IN NANOPARTICLES ON BLADDER CANCER CELLS AND UROTHELIAL TISSUES
Saltzman A, Woodrow K, Wheeler M, Verma A, Saltzman W, Weiss R. 436 EFFECT OF SURVIVIN SIRNA AND VEGF SIRNA COMPLEXED IN NANOPARTICLES ON BLADDER CANCER CELLS AND UROTHELIAL TISSUES. Journal Of Urology 2010, 183: e172-e173. DOI: 10.1016/j.juro.2010.02.507.Peer-Reviewed Original Research1153 EFFECT OF MITOMYCIN C ON LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS IN BLADDER CANCER CELLS AND IN BLADDERS OF RATS INTRAVESICALLY INSTILLED WITH MITOMYCIN C
Verma A, Wheeler M, DeGrado J, Kaimakliotis H, Hittelman A, Weiss R. 1153 EFFECT OF MITOMYCIN C ON LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS IN BLADDER CANCER CELLS AND IN BLADDERS OF RATS INTRAVESICALLY INSTILLED WITH MITOMYCIN C. Journal Of Urology 2010, 183: e446-e447. DOI: 10.1016/j.juro.2010.02.652.Peer-Reviewed Original Research
2008
Prostate expression of endothelins and their receptors in rat growth
Wada Y, Takahashi W, Latifpour J, Weiss RM, Matsumoto K, Matsui K, Yamada, Imamura T. Prostate expression of endothelins and their receptors in rat growth. Reproduction Fertility And Development 2008, 20: 750-759. PMID: 18842177, DOI: 10.1071/rd08052.Peer-Reviewed Original ResearchConceptsET-1Receptors ETAProstate growthProstate lobesET-3Role of ETAVentral prostate lobeReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMultiplex reverse transcription-polymerase chain reactionMRNA expression levelsProstate expressionEndothelinMitogenic effectProstate cellsMRNA expressionMembrane particulatesHigh expressionMonthsWeeksEnzyme 1Chain reactionExpression levelsRat growthRats