2024
Unveiling the Structure in Mental Disorder Presentations
Spiller T, Duek O, Helmer M, Murray J, Fielstein E, Pietrzak R, von Känel R, Harpaz-Rotem I. Unveiling the Structure in Mental Disorder Presentations. JAMA Psychiatry 2024, 81: 1101-1107. PMID: 39110437, PMCID: PMC11307158, DOI: 10.1001/jamapsychiatry.2024.2047.Peer-Reviewed Original ResearchSymptom combinationsNational Institute of Mental Health Data ArchivePosttraumatic stress disorderDiagnostic criteriaHeterogeneity of symptomsSecondary data analysisCross-sectional studyRevision of diagnostic criteriaSymptom-based definitionsDSM criteriaStress disorderSymptom heterogeneityDisorder presentationsClinical populationsMain OutcomesAssess symptomsGroup of individualsParticipantsSymptomsNational InstituteDisordersIndividualsSchizophreniaAnxietyIndividual frequenciesPosttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81 PMID: 39476130, PMCID: PMC11581715, DOI: 10.1001/jamapsychiatry.2024.3403.Peer-Reviewed Original ResearchPrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationSuccessful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study
Shin J, Fischer I, Na P, Jeste D, Pietrzak R. Successful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2024 PMID: 39214753, DOI: 10.1016/j.jagp.2024.07.018.Peer-Reviewed Original ResearchGeneralized anxiety disorderPosttraumatic stress disorderMental disordersSomatic symptomsNational Health and ResilienceUS military veteransSuccessful agingAnxiety disordersDepressive disorderUS veteransStress disorderPromote successful agingHigher gratitudeVeterans StudyMilitary veteransInterventions targeting psychosocial factorsOne-in-fiveVeteransMDDDisordersPsychosocial factorsGratitudeNegative associationSymptomsMultivariate logistic regressionRole of homelessness and psychiatric disorders in suicide deaths among veterans: A four-way decomposition analysis
Beydoun H, Szymkowiak D, Pietrzak R, Beydoun M, Treadwell R, Tsai J. Role of homelessness and psychiatric disorders in suicide deaths among veterans: A four-way decomposition analysis. Psychiatry Research 2024, 340: 116120. PMID: 39121758, DOI: 10.1016/j.psychres.2024.116120.Peer-Reviewed Original ResearchMental health disordersFour-way decomposition analysisSubstance useHealth disordersPsychiatric disordersMortality riskSuicide deathsHomeless veteransVeterans AffairsSubstance use disordersU.S. Department of Veterans AffairsDepartment of Veterans AffairsPredictors of suicide deathVA healthcare systemFully-adjusted modelsMental health characteristicsEffects of homelessnessProportion of suicide deathsSuicide riskUse disorderHealth characteristicsRetrospective cohort studySuicideHealthcare systemDisordersW35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original Research
2022
Homelessness and Contact with the Criminal Legal System among U.S. Combat Veterans: An Exploration of Potential Mediating Factors
Orak U, Kelton K, Vaughn M, Tsai J, Pietrzak R. Homelessness and Contact with the Criminal Legal System among U.S. Combat Veterans: An Exploration of Potential Mediating Factors. Criminal Justice And Behavior 2022, 50: 392-409. DOI: 10.1177/00938548221140352.Peer-Reviewed Original ResearchCombat veteransUse disordersCLS involvementU.S. combat veteransDrug use disordersAlcohol use disorderPotential mediating factorsRisk factorsNational HealthModifiable mechanismsHistory of homelessnessVeterans StudyDescriptive studyPrevention effortsPotential mechanismsNotable proportionVeteransInvolvementDisordersAssociationMoral injuryMediating factorsIndirect associationsLarge proportionPost-traumatic Stress Disorder
Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderStress disorderCognitive processing therapyCognitive behavioral therapyEye movement desensitizationEvidence-based psychotherapiesTraumatic eventsBehavioral therapyNegative alterationsFirst-line pharmacologic treatmentStructured interviewsFirst-line treatmentNonpsychiatric settingsLarge bodyPharmacologic treatmentReuptake inhibitorsCognitionDisordersArousalTherapeutic interventionsMoodPsychotherapyAvoidanceTherapyIntervention
2021
Research on Posttraumatic Stress Disorder in the Context of the COVID-19 Pandemic: A Review of Methods and Implications in General Population Samples
Husky M, Pietrzak R, Marx B, Mazure C. Research on Posttraumatic Stress Disorder in the Context of the COVID-19 Pandemic: A Review of Methods and Implications in General Population Samples. Chronic Stress 2021, 5: 24705470211051327. PMID: 34765850, PMCID: PMC8576091, DOI: 10.1177/24705470211051327.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderGeneral population sampleMental disordersCOVID-19 pandemicPre-existing mental disordersSevere posttraumatic symptomsPopulation samplePublic health planningDirect trauma exposurePosttraumatic stress disorder (PTSD) symptomsCross-sectional designGeneral populationSnowball sampling strategiesHealth planningTrauma exposureMental healthStatistical ManualDisordersDisorder symptomsInadequate assessmentCriterion ASymptomsPosttraumatic symptomsSelf-report measures
2015
Epidemiology of generalized anxiety disorder in Canadian military personnel
Erickson J, Kinley D, Afifi T, Zamorski M, Pietrzak R, Stein M, Sareen J. Epidemiology of generalized anxiety disorder in Canadian military personnel. Journal Of Military Veteran And Family Health 2015, 1: 26-36. DOI: 10.3138/jmvfh.2014-01.Peer-Reviewed Original ResearchMental disordersHigher oddsWorld Mental Health Composite International Diagnostic InterviewComposite International Diagnostic InterviewMultivariate logistic regression modelAnxiety disordersMilitary personnelConsiderable functional impairmentCo-occurring disordersCanadian Community Health Survey-Canadian Forces SupplementLifetime prevalence ratesMental health careRegular Force personnelDegree of impairmentCanadian military personnelGeneralized anxiety disorderLogistic regression modelsClinical characteristicsClinical featuresMean ageFunctional impairmentPrevalence ratesDiagnostic InterviewEpisode lengthDisordersComorbidity and functional correlates of anxiety and physical conditions in Canadian Veterans
El-Gabalawy R, Thompson J, Sweet J, Erickson J, Mackenzie C, Pietrzak R, VanTil L, Sareen J. Comorbidity and functional correlates of anxiety and physical conditions in Canadian Veterans. Journal Of Military Veteran And Family Health 2015, 1: 37-46. DOI: 10.3138/jmvfh.2014-03.Peer-Reviewed Original ResearchHealth-related qualityPoorer physical health-related qualityPhysical health-related qualityMusculoskeletal conditionsActivity limitationsAnxiety disordersChronic painCanadian VeteransMental health-related qualityCorrelates of comorbidityCo-occurring anxiety disordersChronic physical conditionsComorbidity of anxietyRegular Force personnelPhysical health problemsMood disordersHealth promotionComorbiditiesHealth problemsRisk personnelFunctional correlatesHeavy drinkingPrevention effortsDisordersMilitary characteristics