2022
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular Psychiatry 2022, 27: 5007-5019. PMID: 36447010, PMCID: PMC9949887, DOI: 10.1038/s41380-022-01880-5.Peer-Reviewed Original ResearchConceptsTourette syndromeInterneuron deficitsGABAergic interneuronsHealthy controlsNeurodevelopmental underpinningsNeuropathological deficitsBG circuitryNeuropsychiatric disordersDecreased differentiationT patientsInterneuronsAltered expressionPotential mechanismsCilia disruptionSonic hedgehogOrganoidsStem cellsTS individualsPluripotent stem cellsGli transcription factorsDeficitsOrganoid differentiationEarly stagesCholinergicPatients
2017
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King R, Pang Z, Xing J, Heiman G, Tischfield J. The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Molecular Psychiatry 2017, 23: 1487-1495. PMID: 28894297, PMCID: PMC5847395, DOI: 10.1038/mp.2017.179.Peer-Reviewed Original ResearchConceptsNonsense-mediated mRNA decayNonsense mutationMultiplex familiesPluripotent stem cellsTD phenotypeDeleterious sequence variantsGenetic architectureMRNA decayHouse bioinformatics pipelineDNA sequencesBioinformatics pipelineTD familyWhole-exome sequencingSequence variantsBiochemical assaysMolecular differencesWhole exomeIsoform levelsStem cellsProtein levelsTD etiologyExome sequencingPNKDHeterozygous nonsense mutationGenesGenetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome
Hirschtritt M, Darrow S, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman C, Cath D, Greenberg E, Lyon G, Yu D, McGrath L, McMahon W, Lee P, Delucchi K, Scharf J, Mathews C. Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. Psychological Medicine 2017, 48: 279-293. PMID: 28651666, PMCID: PMC7909616, DOI: 10.1017/s0033291717001672.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSymmetry/exactnessTourette syndromeLatent class analysisSymptom patternsADHD symptomsHigher psychiatric comorbidity ratesPsychiatric comorbidity ratesExploratory factor analysisHyperactive subtypeComorbidity ratesTS patientsClinical relevanceSpecific subtypesSum scoreUnique phenotypicHyperactivity disorderSymptomsPhenotypic overlapThree-class solutionTraditional diagnostic boundariesAggressive urgesSyndromeSubtypesDiagnostic boundaries
2012
Genome-wide association study of Tourette's syndrome
Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff R, Wagner M, Moessner R, Mirel D, Posthuma D, Sabatti C, Eskin E, Conti D, Knowles J, Ruiz-Linares A, Rouleau G, Purcell S, Heutink P, Oostra B, McMahon W, Freimer N, Cox N, Pauls D. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2012, 18: 721-728. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesChromosomes, Human, Pair 9FemaleFibrillar CollagensGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansInternational CooperationMaleMeta-Analysis as TopicObsessive-Compulsive DisorderPolymorphism, Single NucleotideTourette SyndromeWhite PeopleYoung AdultConceptsGenome-wide association studiesFirst genome-wide association studyAssociation studiesTop signalsFull genetic architectureAncestry-matched controlsEuropean ancestry samplesGenetic architectureGWAS dataComplex inheritanceEuropean-derived populationsSusceptibility variantsSusceptibility genesEventual identificationEuropean ancestryCosta RicaChromosome 9q32Familial recurrence rateNorth AmericaComplete understandingAmerican populationCentral ValleyNeuropsychiatric diseasesDevelopmental disordersGenes
2007
A Chronological Perspective on Suicide—The Last Days of Life
Orbach I, Gilboa-Schechtman E, Ofek H, Lubin G, Mark M, Bodner E, Cohen D, King R. A Chronological Perspective on Suicide—The Last Days of Life. Death Studies 2007, 31: 909-932. PMID: 17924514, DOI: 10.1080/07481180701603394.Peer-Reviewed Original Research
2006
PANDAS: to treat or not to treat?
King RA. PANDAS: to treat or not to treat? Advances In Neurology 2006, 99: 179-83. PMID: 16536364.Peer-Reviewed Original Research
2005
Regarding “Antibiotic Prophylaxis with Azithromycin or Penicillin for Childhood-Onset Neuropsychiatric Disorders”
Group T, Budman C, Coffey B, Dure L, Gilbert D, Juncos J, Kaplan E, King R, Kurlan R, Lowe T, Mack K, Mink J, Schlaggar B, Singer H. Regarding “Antibiotic Prophylaxis with Azithromycin or Penicillin for Childhood-Onset Neuropsychiatric Disorders”. Biological Psychiatry 2005, 58: 917. PMID: 16242121, DOI: 10.1016/j.biopsych.2005.08.005.Peer-Reviewed Original Research
2001
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
Morshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.Peer-Reviewed Original ResearchConceptsTotal antinuclear antibodiesAntinuclear antibodiesAutoimmune disordersTourette syndromeAnticytoskeletal antibodiesAntineural antibodiesStreptococcal infectionT patientsTS patientsBeta-hemolytic streptococcal infectionPrior streptococcal infectionHemolytic streptococcal infectionAntistreptolysin O titerIndirect immunofluorescent assayLevels of immunoreactivityWestern blot techniqueMean rankClinical characteristicsSydenham's choreaO titerPatient groupSC patientsIgG antibodiesIgG classNormal controlsPsychosocial and Risk Behavior Correlates of Youth Suicide Attempts and Suicidal Ideation
KING R, SCHWAB-STONE M, FLISHER A, GREENWALD S, KRAMER R, GOODMAN S, LAHEY B, SHAFFER D, GOULD M. Psychosocial and Risk Behavior Correlates of Youth Suicide Attempts and Suicidal Ideation. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 837-846. PMID: 11437023, DOI: 10.1097/00004583-200107000-00019.Peer-Reviewed Original ResearchConceptsSuicidal ideationRisk behavior correlatesStressful life eventsCurrent smokingLow parental monitoringAdolescent Mental Disorders (MECA) StudySignificant associationRisk behaviorsPoor family environmentEpidemiology of ChildParental psychiatric historySexual activityMental Disorders StudyLife eventsNIMH MethodsPsychiatric historyPsychiatric disordersDisruptive disordersPhysical fightingBehavior correlatesSociodemographic characteristicsSuicide attemptsFamily environmentSociodemographic variablesSubject characteristicsAre child-, adolescent-, and adult-onset depression one and the same disorder?
Kaufman J, Martin A, King R, Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder? Biological Psychiatry 2001, 49: 980-1001. PMID: 11430841, DOI: 10.1016/s0006-3223(01)01127-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntidepressive Agents, TricyclicAnti-Inflammatory AgentsBrainChildCorticotropin-Releasing HormoneDepressive Disorder, MajorDexamethasoneDiagnosis, DifferentialGrowth Hormone-Releasing HormoneHumansHydrocortisoneImmunity, CellularMagnetic Resonance ImagingSerotoninThyroid HormonesConceptsAdult-onset depressionBasal cortisol secretionStage of illnessSerotonergic probeTricyclic medicationDepressed cohortClinical outcomesCortisol secretionHormone infusionIllness factorsTreatment responsePreclinical studiesSame disorderDepressed adultsImmunity indicesDepression oneFamilial subtypeNeurobiological assessmentNeurobiological correlatesChildrenAdolescentsIllnessDiscrepant findingsNeuroimaging paradigmDepressionCase control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents
Zalsman G, Frisch A, King R, Pauls D, Grice D, Gelernter J, Alsobrook J, Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman J. Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. American Journal Of Medical Genetics 2001, 105: 451-457. PMID: 11449398, DOI: 10.1002/ajmg.1406.Peer-Reviewed Original ResearchConceptsSuicidal behaviorSuicide riskA218C polymorphismDetailed clinical historyHaplotype relative riskAssociation of suicidalityTransmission disequilibrium test (TDT) methodsTryptophan hydroxylase geneAdolescent suicidal behaviorClinical historySame ethnic populationRelative riskCase controlAA genotypeControl groupFamily-based studySuicide intentSignificant allelic associationSignificant differencesEthnic populationsStructured interviewsInpatient adolescentsRiskAssociationSuicidalityEmotional and behavioral difficulties associated with Tourette syndrome.
King R, Scahill L. Emotional and behavioral difficulties associated with Tourette syndrome. Advances In Neurology 2001, 85: 79-88. PMID: 11530448.Peer-Reviewed Original Research
2000
Risk Behavior in a Community Sample of Children and Adolescents
FLISHER A, KRAMER R, HOVEN C, KING R, BIRD H, DAVIES M, GOULD M, GREENWALD S, LAHEY B, REGIER D, SCHWAB-STONE M, SHAFFER D. Risk Behavior in a Community Sample of Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 881-887. PMID: 10892230, DOI: 10.1097/00004583-200007000-00017.Peer-Reviewed Original ResearchConceptsRisk behaviorsFunctional impairmentAdolescent Mental Disorders (MECA) StudyFamily psychiatric disordersEpidemiology of ChildMental Disorders StudySuicidal ideation/attemptsPotential correlatesCigarette smokingOdds ratioCommunity probability sampleMarijuana smokingPsychiatric disordersLinear regression analysisAlcohol useDisorders StudySmokingRegression analysisChildrenCommunity sampleProbability sampleAdolescentsImpairmentPsychopathologySignificant relationshipPharmacologic Treatment of Tic Disorders
Scahill L, Chappell P, King R, Leckman J. Pharmacologic Treatment of Tic Disorders. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 99-117. PMID: 10674192, DOI: 10.1016/s1056-4993(18)30137-8.Peer-Reviewed Original ResearchConceptsTic disordersTreatment of ADHDAtypical neurolepticsLong-term side effectsNewer atypical neurolepticsFirst-line treatmentTreatment of ticsBotulinum toxin injectionMore studiesUse of stimulantsNonstimulant medicationsToxin injectionPharmacologic treatmentPsychiatric comorbidityStandard treatmentTraditional neurolepticsTarget symptomsSide effectsStimulant medicationMedicationsNeurolepticsAdverse effectsComorbid ADHDDisordersTreatment planning
1998
Psychopathology Associated With Suicidal Ideation and Attempts Among Children and Adolescents
GOULD M, KING R, GREENWALD S, FISHER P, SCHWAB-STONE M, KRAMER R, FLISHER A, GOODMAN S, CANINO G, SHAFFER D. Psychopathology Associated With Suicidal Ideation and Attempts Among Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 915-923. PMID: 9735611, DOI: 10.1097/00004583-199809000-00011.Peer-Reviewed Original ResearchConceptsSubstance abuse/dependenceAbuse/dependenceSuicidal ideationSuicide attemptsPsychiatric disordersSubstance abuse/dependence disordersAdolescent Mental Disorders (MECA) StudySuicide riskNoncriterion symptomsChildren Version 2.3Epidemiology of ChildAge-specific riskDiagnostic Interview ScheduleMental Disorders StudyLogistic regression analysisDependence disordersDisruptive disordersPanic attacksSignificant independent contributionSociodemographic characteristicsRisk profileSuicidal thoughtsSpecific disordersSuicide attemptersSymptom correlatesOBSESSIVE-COMPULSIVE DISORDER AND SEPARATION ANXIETY
Martin A, Scahill L, Vitulano L, King R. OBSESSIVE-COMPULSIVE DISORDER AND SEPARATION ANXIETY. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 350-351. PMID: 9549953, DOI: 10.1097/00004583-199804000-00010.Peer-Reviewed Original ResearchSTIMULANT USE AND TRICHOTILLOMANIA
Martin A, Scahill L, Vitulano L, King R. STIMULANT USE AND TRICHOTILLOMANIA. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 349-350. PMID: 9549952, DOI: 10.1097/00004583-199804000-00009.Peer-Reviewed Original Research
1997
Thresholds and Tolerance of Physical Pain in Suicidal and Nonsuicidal Adolescents
Orbach I, Mikulincer M, King R, Cohen D, Stein D. Thresholds and Tolerance of Physical Pain in Suicidal and Nonsuicidal Adolescents. Journal Of Consulting And Clinical Psychology 1997, 65: 646-652. PMID: 9256566, DOI: 10.1037/0022-006x.65.4.646.Peer-Reviewed Original ResearchChildren's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity
Scahill L, Riddle M, McSwiggin-Hardin M, Ort S, King R, Goodman W, Cicchetti D, Leckman J. Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 844-852. PMID: 9183141, DOI: 10.1097/00004583-199706000-00023.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleYale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderObsessive-compulsive symptom severityManifest Anxiety ScaleObsessive-compulsive symptomsObsessive Compulsive ScaleChildren's Manifest Anxiety ScaleCompulsive ScaleCY-BOCS total scoreSymptom severityDepression InventoryChildren's Depression InventoryTotal scoreCY-BOCS scoresAnxiety ScaleConvergent validityValid subscalesInternal consistencyCompulsion scoreAdolescentsSubscalesChildrenInterrater agreementValidityRitual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children
Evans D, Leckman J, Carter A, Reznick J, Henshaw D, King R, Pauls D. Ritual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children. Child Development 1997, 68: 58-68. PMID: 9084125, DOI: 10.1111/j.1467-8624.1997.tb01925.x.Peer-Reviewed Original Research