2002
Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure
Homer RJ, Zheng T, Chupp G, He S, Zhu Z, Chen Q, Ma B, Hite RD, Gobran LI, Rooney SA, Elias JA. Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2002, 283: l52-l59. PMID: 12060560, DOI: 10.1152/ajplung.00438.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsthmaBronchoalveolar Lavage FluidGene ExpressionHypertrophyImmunohistochemistryInterleukin-13MiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicProteolipidsPulmonary AlveoliPulmonary FibrosisPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRNA, MessengerConceptsType II cell hypertrophyIL-13Cell hypertrophyChronic pulmonary conditionsPathogenesis of asthmaBronchoalveolar lavage fluidTh2-mediated immunityIL-13 exposureProminent interstitial fibrosisWild-type miceAirway hyperresponsivenessMucus metaplasiaEosinophilic inflammationPulmonary diseaseInterstitial fibrosisLavage fluidPulmonary conditionsTwo- to threefold increaseSurfactant accumulationLittermate controlsPotent stimulatorSurfactant phospholipidsFibrosisKey mediatorHypertrophy
2001
Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1
Lee C, Homer R, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley J, Gotwals P, Noble P, Chen Q, Senior R, Elias J. Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1. Journal Of Experimental Medicine 2001, 194: 809-822. PMID: 11560996, PMCID: PMC2195954, DOI: 10.1084/jem.194.6.809.Peer-Reviewed Original ResearchConceptsIL-13Fibrogenic effectsT helper cell type 2 inflammationTissue fibrosisIL-13 overexpressionMMP-9 null miceType 2 inflammationTransforming Growth Factor-β1Wild-type miceGrowth factor-β1Pulmonary fibrosisTGF-beta pathwayFactor-β1Matrix metalloproteinasePotent stimulatorFibrosisNull miceTGFPlasminogen activatorDecreased levelsKey mediatorMiceGrowth factorUrinary plasminogen activatorProtein 1