2017
Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy
Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King‐Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia 2017, 58: 994-1004. PMID: 28398014, DOI: 10.1111/epi.13740.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisSeizure-free periodTemporal lobe epilepsySeizure reductionAdverse eventsLobe epilepsyIntractable mesial temporal lobe epilepsySerious device-related adverse eventsIntractable partial-onset seizuresMedian percent seizure reductionMesial temporal lobe originBilateral mesial temporal lobe epilepsyDevice-related adverse eventsBrain-responsive neurostimulationImplant site infectionPercent seizure reductionPartial-onset seizuresProspective clinical trialsTemporal lobe originVagus nerve stimulationEffective treatment optionPercent of subjectsPreimplantation baselineTemporal sclerosis
2013
7T MR spectroscopic imaging in the localization of surgical epilepsy
Pan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAspartic AcidCreatineElectroencephalographyEpilepsy, Temporal LobeFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedTreatment OutcomeYoung AdultConceptsSevere metabolic abnormalitiesLocalization-related epilepsyMR spectroscopic imagingN-acetyl aspartateComplete resectionMetabolic abnormalitiesBetter outcomesMedial temporal lobe epilepsyResection regionTemporal lobe epilepsyNAA/CrSeizure onset zoneSurgical resectionLobe epilepsySurgical approachSeizure localizationMetabolic dysfunctionInternational LeagueSurgical epilepsyGray matterEpilepsyResectionAbnormalitiesMRSI abnormalitiesOutcome prediction
2012
Metabolic networks in epilepsy by MR spectroscopic imaging
Pan JW, Spencer DD, Kuzniecky R, Duckrow RB, Hetherington H, Spencer SS. Metabolic networks in epilepsy by MR spectroscopic imaging. Acta Neurologica Scandinavica 2012, 126: 411-420. PMID: 22574807, PMCID: PMC3600585, DOI: 10.1111/j.1600-0404.2012.01665.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainElectroencephalographyEpilepsy, Temporal LobeFemaleHumansMagnetic Resonance SpectroscopyMaleMetabolic Networks and PathwaysYoung AdultConceptsMTLE patientsBasal gangliaEpileptic networkMesial temporal lobe epilepsy patientsTemporal lobe epilepsy patientsLimbic seizure propagationBilateral basal gangliaNAA/CrMR spectroscopicIpsilateral insulaSeizure propagationBilateral hippocampusEpilepsy patientsHuman studiesIndependent factorsPatientsNeuronal functionThalamusGangliaEpilepsyInsulaFactor analysisFactorsHippocampusInjury
2009
Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies
Goncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS. Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies. Epilepsia 2009, 50: 2575-2585. PMID: 19674048, DOI: 10.1111/j.1528-1167.2009.02258.x.Peer-Reviewed Original ResearchConceptsMedial temporal structuresInterictal spikesLT patientsCortical areasNeocortical seizure onsetsSleep-related increaseSpike rateLateral temporal epilepsyExtratemporal areasTemporal epilepsySeizure onsetIntracranial monitoringLT groupMT groupPatientsFrontal spikesSeizuresGreater numberSleepGroupTemporal structureEpilepsySpikesLocalization-related epilepsy exhibits significant connectivity away from the seizure-onset area
Zaveri HP, Pincus SM, Goncharova II, Duckrow RB, Spencer DD, Spencer SS. Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area. Neuroreport 2009, 20: 891-895. PMID: 19424095, DOI: 10.1097/wnr.0b013e32832c78e0.Peer-Reviewed Original ResearchConceptsSeizure onset areaLocalization-related epilepsyControl of seizuresDiscrete cortical areasStandard clinical proceduresBeta frequency bandsUnselected patientsComplete resectionEpilepsy surgeryCortical areasFunctional connectivitySeizuresClinical proceduresEpilepsyIntracranial electroencephalogramSignificant connectivityResectionPatientsSurgery
2005
Normal magnetic resonance imaging and medial temporal lobe epilepsy: the clinical syndrome of paradoxical temporal lobe epilepsy.
Cohen-Gadol AA, Bradley CC, Williamson A, Kim JH, Westerveld M, Duckrow RB, Spencer DD. Normal magnetic resonance imaging and medial temporal lobe epilepsy: the clinical syndrome of paradoxical temporal lobe epilepsy. Journal Of Neurosurgery 2005, 102: 902-9. PMID: 15926717, DOI: 10.3171/jns.2005.102.5.0902.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyMedial temporal sclerosisTemporal lobe epilepsyAnteromedial temporal resectionPTLE groupDentate granule cellsLobe epilepsyMTS groupTemporal resectionClinical featuresNeuron lossSeizure historyHippocampal slicesGranule cellsNormal magnetic resonance imagingBlinded visual inspectionPyramidal cell lossDistinct clinical featuresHippocampal cell densityT2 signal changeSignificant neuron lossHippocampal volumetric measurementsMagnetic resonance imagingVolumetric measurementsSharp electrode recordings
2001
Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal Activity
Zaveri H, Duckrow R, De Lanerolle N, Spencer S. Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal Activity. Epilepsia 2001, 42: 725-730. PMID: 11422326, DOI: 10.1046/j.1528-1157.2001.00500.x.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisTemporal lobe epilepsyLobe epilepsySurgical outcomesIntractable temporal lobe epilepsyPoor surgical outcomesGood surgical outcomeMedial temporal structuresMedial temporal lobeDelta band powerTemporal sclerosisRetrospective studyHippocampal tissueBackground EEGSeizure onsetIndividual patientsSurgical proceduresIntracranial monitoringTemporal lobeGamma frequency bandClinical observationsPatientsAnterior hippocampusCell lossSubtypes