2015
Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
Bergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, Noe K, Wharen R, Worrell G, Murro AM, Edwards J, Duchowny M, Spencer D, Smith M, Geller E, Gwinn R, Skidmore C, Eisenschenk S, Berg M, Heck C, Van Ness P, Fountain N, Rutecki P, Massey A, O'Donovan C, Labar D, Duckrow RB, Hirsch LJ, Courtney T, Sun FT, Seale CG. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology 2015, 84: 810-817. PMID: 25616485, PMCID: PMC4339127, DOI: 10.1212/wnl.0000000000001280.Peer-Reviewed Original ResearchConceptsRefractory partial-onset seizuresPartial-onset seizuresRefractory partial seizuresOnset seizuresQuality of lifePartial seizuresResponsive neurostimulatorSerious device-related adverse eventsMedian percent seizure reductionGeneralized tonic-clonic seizuresOpen-label safety studyDevice-related adverse eventsImplant site infectionPercent seizure reductionResponsive brain stimulationClass IV evidenceTonic-clonic seizuresDirect cortical stimulationLong-term efficacyLong-term treatmentRNS SystemDirect neurostimulationSeizure reductionAdverse eventsSite infection
1981
Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism
Harik SI, Duckrow RB, LaManna JC, Rosenthal M, Sharma VK, Banerjee SP. Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism. Journal Of Neuroscience 1981, 1: 641-649. PMID: 7346572, PMCID: PMC6564177, DOI: 10.1523/jneurosci.01-06-00641.1981.Peer-Reviewed Original ResearchConceptsLocus ceruleus lesionNoradrenergic denervationCerebral cortexReceptor bindingNoradrenergic receptor bindingOxidative metabolismRat cerebral cortexDirect cortical stimulationVivo oxidative metabolismBlood volume shiftsCyclic AMP generationAdenylate cyclase activityCerebral compensationNoradrenaline depletionLocus ceruleusUnilateral injectionCortical stimulationCerebral noradrenalineLong-term effectsAMP generationMonophosphate generationLesionsDenervationCyclase activityWeeks