2024
Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRace
2023
Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study
Mangino J, Firstenberg M, Milewski R, Rhys-Williams W, Lees J, Dane A, Love W, Moreno J. Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study. Infection Control And Hospital Epidemiology 2023, 44: 1171-1173. PMID: 36951472, PMCID: PMC10369221, DOI: 10.1017/ice.2023.17.Peer-Reviewed Original Research
2022
Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly intervention
2018
Hypoxia and Complications of Oxygenation in Extracorporeal Membrane Oxygenation
Alexis-Ruiz A, Ghadimi K, Raiten J, Mackay E, Laudanski K, Cannon J, Ramakrishna H, Evans A, Augoustides J, Vallabhajosyula P, Milewski R, McDonald M, Patel P, Vernick W, Gutsche J. Hypoxia and Complications of Oxygenation in Extracorporeal Membrane Oxygenation. Journal Of Cardiothoracic And Vascular Anesthesia 2018, 33: 1375-1381. PMID: 30082128, DOI: 10.1053/j.jvca.2018.05.028.Peer-Reviewed Educational Materials
2017
Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation
Diamond J, Cantu E, Porteous M, Suzuki Y, Meyer K, Lederer D, Milewski R, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett J, Singh G, Costa J, Tobias J, Rodriguez H, Van Deerlin V, Olthoff K, Shaked A, Chang B, Christie J, Investigators T. Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal Of Transplantation 2017, 17: 1770-1777. PMID: 28117940, PMCID: PMC5489369, DOI: 10.1111/ajt.14209.Peer-Reviewed Original ResearchConceptsPrimary graft dysfunctionGraft dysfunctionLung transplantationPeripheral blood gene expressionFirst transplant yearImmune regulation genesInflammasome-related proteinsDays of transplantBlood of patientsAdaptive immunity genesBlood gene expressionAllograft reperfusionTransplant yearClinical trialsPGD developmentGrade 3T cellsTransplantGene expressionHypothesis-driven genesRNA expressionGene expression changesReperfusionAllograftsPatients
2016
The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction
Abbas A, Diamond J, Chehoud C, Chang B, Kotzin J, Young J, Imai I, Haas A, Cantu E, Lederer D, Meyer K, Milewski R, Olthoff K, Shaked A, Christie J, Bushman F, Collman R. The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction. American Journal Of Transplantation 2016, 17: 1313-1324. PMID: 27731934, PMCID: PMC5389935, DOI: 10.1111/ajt.14076.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesDNA, ViralFemaleFollow-Up StudiesGenome, ViralGraft RejectionGraft SurvivalHumansLung TransplantationMaleMetagenomicsMiddle AgedPerioperative CarePrimary Graft DysfunctionPrognosisProspective StudiesRespiratory SystemRisk FactorsTissue DonorsTorque teno virusConceptsPrimary graft dysfunctionTorque teno virusGraft dysfunctionDonor lungsTTV levelsGreater immune activationTTV DNA levelsStandard clinical assaysRespiratory tract bacteriaPGD casesQuantitative polymerase chain reactionEarly morbidityLung allograftsLung transplantationPGD statusTTV replicationBronchoalveolar lavageControl recipientsImmune activationPolymerase chain reactionHealthy controlsBrain deathRecipient pairsTissue injuryDonor organs