2009
HOXA11 Promotes Fibroblast Proliferation and Regulates p53 in Uterosacral Ligaments
Connell KA, Guess MK, Chen HW, Lynch T, Bercik R, Taylor HS. HOXA11 Promotes Fibroblast Proliferation and Regulates p53 in Uterosacral Ligaments. Reproductive Sciences 2009, 16: 694-700. PMID: 19372592, PMCID: PMC3107841, DOI: 10.1177/1933719109334260.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCells, CulturedFemaleFibroblastsHomeodomain ProteinsHumansLigamentsMiceNIH 3T3 CellsSacrumTumor Suppressor Protein p53UterusConceptsCell proliferationExtracellular matrix proteinsTumor suppressor geneECM genesExpression of HOXA11Cell cycleMatrix proteinsSuppressor geneMurine fibroblastsRegulate p53Phenotypic abnormalitiesGenesHOXA11Rate of proliferationHOXA11 expressionExpressionP53ProliferationExpression of p53Fibroblast proliferationKey support structuresProteinHomeostasisDevelopment of POPBetter understandingDiminished vaginal HOXA13 expression in women with pelvic organ prolapse
Connell KA, Guess MK, Tate A, Andikyan V, Bercik R, Taylor HS. Diminished vaginal HOXA13 expression in women with pelvic organ prolapse. Menopause The Journal Of The North American Menopause Society 2009, 16: 529-533. PMID: 19423998, PMCID: PMC2704499, DOI: 10.1097/gme.0b013e31818fb0c2.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesFemaleHomeodomain ProteinsHumansMiddle AgedUterine ProlapseVaginaConceptsPelvic organ prolapsePremenopausal controlsPremenopausal womenOrgan prolapseHOXA13 expressionPOP groupExpression of HOXA13Real-time polymerase chain reactionExtracellular matrix metabolismEstrogen therapyPostmenopausal womenYounger patientsLeuprolide groupSmoking cessationLeuprolide acetatePolymerase chain reactionBiopsy specimensPreventive strategiesGenetic predispositionVaginal expressionProlapseMatrix metabolismWeight lossWomenVagina
2008
HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse
Connell KA, Guess MK, Chen H, Andikyan V, Bercik R, Taylor HS. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. Journal Of Clinical Investigation 2008, 118: 1050-1055. PMID: 18274672, PMCID: PMC2242622, DOI: 10.1172/jci34193.Peer-Reviewed Original Research