B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.
Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. The Journal Of Immunology 1999, 163: 2322-9. PMID: 10438978, DOI: 10.4049/jimmunol.163.4.2322.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibodies, BlockingAntibodies, MonoclonalAntigens, CDAutoantibodiesB7-1 AntigenB7-2 AntigenDNAGlomerulonephritisKidneyLupus Erythematosus, SystemicLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearConceptsMRL-lpr/lpr miceAnti-dsDNA autoantibodiesSystemic lupus erythematosusLpr miceAutoantibody expressionLupus erythematosusB7 costimulationAb treatmentMRL-lpr/lpr murine modelAnti-small nuclear ribonucleoproteinAge-matched wild-type miceHuman systemic lupus erythematosusMurine systemic lupus erythematosusDevelopment of lupusB7 costimulatory signalsWild-type miceB7.1/B7.2Autoantibody titersSevere glomerulonephritisSurface of APCsAutoantibody profileUntreated miceCostimulatory moleculesKidney pathologyT lymphocytesIsoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse