2013
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.Peer-Reviewed Original ResearchConceptsHealthy control subjectsAD patientsControl subjectsInpatient treatmentAlcohol cravingAlcohol cuesBrain responsesRelapse riskAlcohol relapseHospital-based research unitAnterior cingulate cortex activationAlcohol-related cuesCommunity mental health centerVentromedial prefrontal functionChronic relapsing illnessVentromedial prefrontal cortexStress-induced cravingAbstinent alcohol-dependent patientsFunctional magnetic resonanceMental health centersAlcohol-dependent patientsSubsequent relapse riskNeural correlatesNeutral trialsHazard ratioDivergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity
Balodis IM, Molina ND, Kober H, Worhunsky PD, White MA, Sinha R, Grilo CM, Potenza MN. Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity 2013, 21: 367-377. PMID: 23404820, PMCID: PMC3610836, DOI: 10.1002/oby.20068.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusCognitive controlBED groupNeural correlatesStroop color-word interference taskColor-word interference taskRight inferior frontal gyrusVentromedial prefrontal cortexDivergent neural substratesFunctional magnetic resonanceInterference taskStroop performanceVmPFC activationDietary restraint scoresInhibitory processingDiminished abilityNeural substratesComparison participantsFrontal gyrusInhibitory controlBiobehavioral processesPrefrontal cortexDietary restraintBehavioral controlRelative hypoactivity
2006
Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing
Li CS, Huang C, Constable RT, Sinha R. Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing. Journal Of Neuroscience 2006, 26: 186-192. PMID: 16399686, PMCID: PMC6674298, DOI: 10.1523/jneurosci.3741-05.2006.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskResponse inhibitionPre-potent response tendenciesReaction timeShorter stop-signal reaction timesEfficient response inhibitionFunctional magnetic resonanceLonger stop-signal reaction timesGroups of subjectsHigher cortical functionsError monitoringNeural correlatesTask demandsHabitual responsesBrain activationNeural substrataResponse tendenciesGreater activationInhibitory controlAffective functionsMotor areaBrain regionsFrontal cortexCortical function