2024
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologyStress and substance use disorders: risk, relapse, and treatment outcomes
Sinha R. Stress and substance use disorders: risk, relapse, and treatment outcomes. Journal Of Clinical Investigation 2024, 134: e172883. PMID: 39145454, PMCID: PMC11324296, DOI: 10.1172/jci172883.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug-related environmentPathophysiology of addictionAdaptive stress responseSUD treatment outcomesAssociated with substance misuseTreatment outcomesStress-related alterationsDrug motivationIncreased cravingNeurobiological disruptionsMaladaptive copingRepeated stressorsTreatment implicationsSubstance misuseStress pathophysiologyStress responseDrug intakeDrug withdrawalRelapse riskDrug misuseIntervention developmentDisordersCravingRelapse
2023
Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse
Milivojevic V, Sinha R. Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse. Current Topics In Behavioral Neurosciences 2023, 1-25. PMID: 37985542, DOI: 10.1007/7854_2023_456.Peer-Reviewed Original ResearchAlcohol use disorderUse disordersHuman laboratory proceduresHuman laboratory modelRelapse riskAlcohol cuesBiobehavioral markersPsychobiological mechanismsStress dysregulationChronic alcohol useAlcohol relapseAlcohol useEffective interventionsNovel interventionsStress biologyReal worldDisordersInterventionCuesSignificant implicationsSignificant treatment challengeHigher relapse riskAUDRisk factorsAdaptation
2022
Cortical profiles of numerous psychiatric disorders and normal development share a common pattern
Cao Z, Cupertino R, Ottino-Gonzalez J, Murphy A, Pancholi D, Juliano A, Chaarani B, Albaugh M, Yuan D, Schwab N, Stafford J, Goudriaan A, Hutchison K, Li C, Luijten M, Groefsema M, Momenan R, Schmaal L, Sinha R, van Holst R, Veltman D, Wiers R, Porjesz B, Lett T, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Robinson L, Smolka M, Walter H, Winterer J, Schumann G, Whelan R, Bhatt R, Zhu A, Conrod P, Jahanshad N, Thompson P, Mackey S, Garavan H. Cortical profiles of numerous psychiatric disorders and normal development share a common pattern. Molecular Psychiatry 2022, 28: 698-709. PMID: 36380235, DOI: 10.1038/s41380-022-01855-6.Peer-Reviewed Original ResearchConceptsCortical thicknessPsychiatric disordersNumerous psychiatric disordersNeurological disordersDesikan-Killiany atlasLower cortical thicknessNormative maturationAllen Human Brain AtlasHealthy adult participantsCortical maturationExpression of PC1Cortical changesEmergence of psychopathologyBrain maturationPsychiatric diseasesMultiple gene ontology categoriesHuman Brain AtlasCortical profilesPubertal transitionCT differencesDisordersLate childhoodABCD studyAdult participantsNeurobiological basisAlcohol’s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder
Sinha R. Alcohol’s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder. Alcohol Research 2022, 42: 12. PMID: 36338609, PMCID: PMC9621746, DOI: 10.35946/arcr.v42.1.12.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disordersNational InstituteEvidence-based diagnosisIntramural Research ProgramAlcohol researchAlcohol-related problemsAlcohol abuseClinical researchMental healthTreatment researchStress neurobiologyDiagnosisPreventionDisordersNIAAAPresentationHealthAlcoholismInstitute
2013
Chapter 23 Stress and Addiction
Sinha R. Chapter 23 Stress and Addiction. 2013, 223-234. DOI: 10.1016/b978-0-12-398336-7.00023-1.Peer-Reviewed Original Research
2007
Connecticut Mental Health Center: Clinical, Research and Training Programs in the Addictions
Schottenfeld R, Carroll K, Kosten T, O'Malley S, Rounsaville B, Sinha R, Kleber H. Connecticut Mental Health Center: Clinical, Research and Training Programs in the Addictions. 2007, 21-49. DOI: 10.1002/9780470994580.ch2.Peer-Reviewed Original ResearchCo-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress
Brady K, Sinha R. Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress. FOCUS The Journal Of Lifelong Learning In Psychiatry 2007, 5: 229-239. DOI: 10.1176/foc.5.2.foc229.Peer-Reviewed Original ResearchSubstance use disordersUse disordersPsychiatric disordersCo-Occurring MentalCo-occurring disordersAttention deficit hyperactivity disorderArea of comorbidityPosttraumatic stress disorderPopulation of peopleDeficit hyperactivity disorderNeurotransmitter systemsMood disordersNeurobiological effectsMental illnessDiagnostic groupsChronic stressNeurobiological interfaceNeural circuitryStress disorderHyperactivity disorderDisordersHigh rateComorbiditiesTechnical advancesIllness
2005
96 Alcohol Abuse and Eating Disorders
Schwartz M, Sinha R. 96 Alcohol Abuse and Eating Disorders. 2005, 1263-1275. DOI: 10.1016/b978-012564370-2/50098-2.Peer-Reviewed Original ResearchAlcohol abusePossible etiological factorsClinical treatment researchRelevant control groupsEtiological factorsTreatment approachesControl groupBulimia nervosaAnorexia nervosaClinical settingPatientsSignificant subgroupEating DisordersDisordersOverall rateTreatment researchCommunity sampleTreatmentNervosaAbuseEDPrevalence
2000
Alcohol and Eating Disorders: Implications for Alcohol Treatment and Health Services Research
Sinha R, O'Malley S. Alcohol and Eating Disorders: Implications for Alcohol Treatment and Health Services Research. Alcohol Clinical And Experimental Research 2000, 24: 1312-1319. PMID: 10968671, DOI: 10.1111/j.1530-0277.2000.tb02097.x.Peer-Reviewed Original ResearchConceptsHealth services research perspectivePossible etiologic associationAlcohol use disorderHealth services researchClinical manifestationsEtiologic associationAlcoholic womenPsychiatric disordersUse disordersAlcohol treatmentClinical implicationsBehavioral treatmentDisordersTreatment implicationsEating DisordersAlcoholismComorbiditiesWomenHigh rateServices researchSubstantial evidenceExpected ratesTreatmentReview
1996
Eating Pathology among Women with Alcoholism and/ or Anxiety Disorders
Sinha R, Robinson J, Merikangas K, Wilson G, Rodin J, O'Malley S. Eating Pathology among Women with Alcoholism and/ or Anxiety Disorders. Alcohol Clinical And Experimental Research 1996, 20: 1184-1191. PMID: 8904968, DOI: 10.1111/j.1530-0277.1996.tb01109.x.Peer-Reviewed Original ResearchConceptsAnxiety disordersWeight concernsSchizophrenia-Lifetime VersionCo-morbid associationsEating Disorder ExaminationEating ConcernAlcoholic womenNonalcoholic womenDisorder NOSPsychiatric diagnosisAffective disordersBulimia nervosaDisorder ExaminationAlcoholismWomenDisordersHigher mean scoresCore psychopathologyMean scoreShape concernsHigh rateOvereatingEating Disorder Examination (EDE) subscalesScoresSubscales