Belief Updating and Paranoia in Individuals With Schizophrenia
Sheffield JM, Suthaharan P, Leptourgos P, Corlett PR. Belief Updating and Paranoia in Individuals With Schizophrenia. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 1149-1157. PMID: 35430406, PMCID: PMC9827723, DOI: 10.1016/j.bpsc.2022.03.013.Peer-Reviewed Original ResearchConceptsBelief updatingThought contentPersecutory delusionsUnusual thought contentHierarchical Gaussian FilterMeasures of anxietyPrior beliefsSignificant indirect effectHealthy control participantsCognitive mechanismsProbabilistic reversalPersecutory beliefsParanoia continuumWorry QuestionnaireNegative Syndrome ScaleControl participantsParanoiaModel implicatingIndirect effectsSymptom Rating ScaleSyndrome ScaleWorryBeliefsSchizophreniaSignificant worryRelating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingTone