2022
Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingTone
2020
Paranoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarm