2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
2022
Belief Updating and Paranoia in Individuals With Schizophrenia
Sheffield JM, Suthaharan P, Leptourgos P, Corlett PR. Belief Updating and Paranoia in Individuals With Schizophrenia. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 1149-1157. PMID: 35430406, PMCID: PMC9827723, DOI: 10.1016/j.bpsc.2022.03.013.Peer-Reviewed Original ResearchConceptsBelief updatingThought contentPersecutory delusionsUnusual thought contentHierarchical Gaussian FilterMeasures of anxietyPrior beliefsSignificant indirect effectHealthy control participantsCognitive mechanismsProbabilistic reversalPersecutory beliefsParanoia continuumWorry QuestionnaireNegative Syndrome ScaleControl participantsParanoiaModel implicatingIndirect effectsSymptom Rating ScaleSyndrome ScaleWorryBeliefsSchizophreniaSignificant worry