2024
Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses
Singh P, Vydyam P, Fang T, Estrada K, Gonzalez L, Grande R, Kumar M, Chakravarty S, Berry V, Ranwez V, Carcy B, Depoix D, Sánchez S, Cornillot E, Abel S, Ciampossin L, Lenz T, Harb O, Sanchez-Flores A, Montero E, Le Roch K, Lonardi S, Mamoun C. Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses. Emerging Microbes & Infections 2024, 13: 2386136. PMID: 39148308, PMCID: PMC11370697, DOI: 10.1080/22221751.2024.2386136.Peer-Reviewed Original ResearchLeveraging genomic informationHuman babesiosisTick-borne diseasesDiseases of significanceCases of human babesiosisGenomic divergenceGenome sequenceGenomic informationMultigene familyGene functionBabesia divergensMammalian hostsAnimal healthMultiomics analysisZoonotic pathogensBabesiosisProtozoan parasitesVirulent strainsPathogensVertebrate hostsEnvironmental changesVirulenceReplication rateAntiparasitic drugsParasites
2023
Uncovering the role of Rad51 in homologous recombination-mediated antigenic diversification in the human malaria parasite Plasmodium falciparum
Vydyam P, Roy N, Bhattacharyya M. Uncovering the role of Rad51 in homologous recombination-mediated antigenic diversification in the human malaria parasite Plasmodium falciparum. Frontiers In Molecular Biosciences 2023, 10: 1223682. PMID: 37593128, PMCID: PMC10427863, DOI: 10.3389/fmolb.2023.1223682.Peer-Reviewed Original ResearchRecombination eventsHuman malaria parasite Plasmodium falciparumAntigenic variationMalaria parasite Plasmodium falciparumRole of RAD51Generation of diversityWhole genome sequencing approachParasite Plasmodium falciparumHuman malaria parasiteMultigene familyGene diversificationRecombinase functionGene repertoireHomologous recombinationGenomic rearrangementsSequencing approachSequence rearrangementsKey molecular factorsParasite linesMolecular determinantsAntigenic diversificationMalaria parasitesChronicity of infectionMolecular factorsImmune evasion mechanisms