2010
High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease
Taddei TH, Dziura J, Chen S, Yang R, Hyogo H, Sullards C, Cohen DE, Pastores G, Mistry PK. High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease. Journal Of Inherited Metabolic Disease 2010, 33: 291-300. PMID: 20354791, PMCID: PMC3008397, DOI: 10.1007/s10545-010-9070-1.Peer-Reviewed Original ResearchConceptsPrevalence of gallstonesType 1 Gaucher diseaseBody mass indexBile lipid analysisGaucher diseaseLipoprotein cholesterolHigh low-density lipoprotein cholesterolLow high-density lipoprotein cholesterolHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolMultiple logistic regression analysisType 1 Gaucher's diseaseBile lipid compositionBiliary lipid secretionCholesterol gallstone diseaseLogistic regression analysisMetabolic syndromeGallstone diseaseLDL cholesterolStudy cohortLipoprotein profileMass indexFemale sexBile compositionBiliary lipids
1984
Abnormal high density lipoproteins from patients with liver disease regulate cholesterol metabolism in cultured human skin fibroblasts.
Owen JS, Goodall H, Mistry P, Harry DS, Day RC, McIntyre N. Abnormal high density lipoproteins from patients with liver disease regulate cholesterol metabolism in cultured human skin fibroblasts. Journal Of Lipid Research 1984, 25: 919-931. PMID: 6491539, DOI: 10.1016/s0022-2275(20)37730-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBinding, CompetitiveCells, CulturedCholesterolElectrophoresis, Polyacrylamide GelFemaleFibroblastsHepatitis, AlcoholicHepatitis, ChronicHumansIsoelectric FocusingLipoproteins, HDLLipoproteins, LDLLiver Cirrhosis, AlcoholicLiver Cirrhosis, BiliaryLiver DiseasesMaleMiddle AgedSucroseConceptsPatients' high-density lipoproteinHigh-density lipoproteinLiver diseaseCholesterol metabolismCultured human skin fibroblastsDensity lipoproteinCell cholesteryl ester contentReceptor activityMicrograms/Human skin fibroblastsAbnormal high-density lipoproteinNormal high density lipoproteinsHDL protein concentrationLow-density lipoproteins bindSkin fibroblastsLDL receptor pathwayCholesteryl ester contentIntracellular cholesterol metabolismCellular cholesterol esterificationHigh-affinity receptorReceptor-mediated pathwayDegradation of 125ICellular cholesterol metabolismLDL catabolismApolipoprotein B