1996
Therapeutic delivery of proteins to macrophages: implications for treatment of Gaucher's disease
Mistry P, Wraight E, Cox T. Therapeutic delivery of proteins to macrophages: implications for treatment of Gaucher's disease. The Lancet 1996, 348: 1555-1559. PMID: 8950883, DOI: 10.1016/s0140-6736(96)04451-0.Peer-Reviewed Original ResearchConceptsGaucher diseaseBone marrowType 1 Gaucher's diseaseActivity of glucocerebrosidaseReceptor-mediated uptakeAcid beta-glucosidase activityAnalysis of bloodAvid uptakeBolus injectionHigh doseGaucher cellsHealthy individualsTracer enzymeGamma scintigraphyReceptor activityMacrophage systemDiseaseLysosomal disordersPlacental enzymeTissue distributionHigh-affinity targetingSaturable uptakePrimary defectScintigraphyVivo
1984
Abnormal high density lipoproteins from patients with liver disease regulate cholesterol metabolism in cultured human skin fibroblasts.
Owen JS, Goodall H, Mistry P, Harry DS, Day RC, McIntyre N. Abnormal high density lipoproteins from patients with liver disease regulate cholesterol metabolism in cultured human skin fibroblasts. Journal Of Lipid Research 1984, 25: 919-931. PMID: 6491539, DOI: 10.1016/s0022-2275(20)37730-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBinding, CompetitiveCells, CulturedCholesterolElectrophoresis, Polyacrylamide GelFemaleFibroblastsHepatitis, AlcoholicHepatitis, ChronicHumansIsoelectric FocusingLipoproteins, HDLLipoproteins, LDLLiver Cirrhosis, AlcoholicLiver Cirrhosis, BiliaryLiver DiseasesMaleMiddle AgedSucroseConceptsPatients' high-density lipoproteinHigh-density lipoproteinLiver diseaseCholesterol metabolismCultured human skin fibroblastsDensity lipoproteinCell cholesteryl ester contentReceptor activityMicrograms/Human skin fibroblastsAbnormal high-density lipoproteinNormal high density lipoproteinsHDL protein concentrationLow-density lipoproteins bindSkin fibroblastsLDL receptor pathwayCholesteryl ester contentIntracellular cholesterol metabolismCellular cholesterol esterificationHigh-affinity receptorReceptor-mediated pathwayDegradation of 125ICellular cholesterol metabolismLDL catabolismApolipoprotein B