Philip Effraim, MD, PhD
Assistant Professor of AnesthesiologyCards
About
Research
Publications
2026
Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain
Ghovanloo M, Effraim P, Tyagi S, Aldrich A, Yuan J, Schulman B, Jacobs D, Dib-Hajj S, Waxman S. Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain. Neurology Genetics 2026, 12: e200367. PMID: 41868096, PMCID: PMC13004580, DOI: 10.1212/nxg.0000000000200367.Peer-Reviewed Original ResearchUtility of Peripheral Nerve Block in Lower Extremity Amputation
Onyewu S, Yanez D, Nnamdi J, Onyewu M, Effraim P. Utility of Peripheral Nerve Block in Lower Extremity Amputation. Journal Of Pain Research 2026, 19: 588924. PMID: 41924087, PMCID: PMC13037648, DOI: 10.2147/jpr.s588924.Peer-Reviewed Original ResearchDendritic spine dysgenesis in spinal cord injury: A structural contributor to pain and spasticity
Kauer S, Effraim P, Bangalore L, Waxman S, Tan A. Dendritic spine dysgenesis in spinal cord injury: A structural contributor to pain and spasticity. Experimental Neurology 2026, 399: 115679. PMID: 41654287, DOI: 10.1016/j.expneurol.2026.115679.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons
Ghovanloo M, Tyagi S, Zhao P, Kiziltug E, Estacion M, Effraim P, Dib-Hajj S, Waxman S. High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons. Nature Protocols 2025, 21: 609-634. PMID: 40514421, PMCID: PMC13037423, DOI: 10.1038/s41596-025-01194-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIn vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine
Ghovanloo M, Tyagi S, Effraim P, Waxman S. In vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine. Journal Of Biological Chemistry 2025, 301: 108407. PMID: 40090585, PMCID: PMC12004706, DOI: 10.1016/j.jbc.2025.108407.Peer-Reviewed Original Research
2024
TRPM8 Mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons
Ghovanloo M, Effraim P, Tyagi S, Aldrich A, Cheng X, Yuan J, Schulman B, Jacobs D, Dib-Hajj S, Waxman S. TRPM8 Mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons. Neurology Genetics 2024, 10: e200206. PMID: 39555137, PMCID: PMC11567650, DOI: 10.1212/nxg.0000000000200206.Peer-Reviewed Original ResearchImpacts of resident physician unionization on house staff compensation
Tyagi S, Shah R, Huttler J, Kayani J, Ghovanloo M, Effraim P. Impacts of resident physician unionization on house staff compensation. PLOS ONE 2024, 19: e0308100. PMID: 39361626, PMCID: PMC11449312, DOI: 10.1371/journal.pone.0308100.Peer-Reviewed Original ResearchNav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia
Nascimento de Lima A, Zhang H, Chen L, Effraim P, Gomis-Perez C, Cheng X, Huang J, Waxman S, Dib-Hajj S. Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain 2024, 147: 3157-3170. PMID: 38447953, DOI: 10.1093/brain/awae071.Peer-Reviewed Original ResearchFunctionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol
Ghovanloo M, Effraim P, Tyagi S, Zhao P, Dib-Hajj S, Waxman S. Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications Biology 2024, 7: 120. PMID: 38263462, PMCID: PMC10805714, DOI: 10.1038/s42003-024-05781-x.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Opioid-Sparing Protocol Comparing With Opioid-based Protocol After Bilateral Total Knee Arthroplasty
IRB ID2000031881RoleSub InvestigatorPrimary Completion Date04/30/2024Recruiting ParticipantsGenderBothAge20 years - 90 years