2023
Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis
Karp E, Williams T, Ellman L, Strauss G, Walker E, Corlett P, Woods S, Powers A, Gold J, Schiffman J, Waltz J, Silverstein S, Mittal V. Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 746-755. PMID: 36939086, PMCID: PMC10154698, DOI: 10.1093/schbul/sbac197.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesGesturesHumansNeuropsychological TestsProdromal SymptomsPsychotic DisordersSelf ReportConceptsClinical high riskGesture deficitsInternalizing disordersCHR groupGesture interpretationLower verbal learningViable assessment toolVerbal learningNeurocognitive tasksGeneral intelligencePerformance deficitsNonverbal behaviorProcessing speedCHR participantsSimilar deficitsGreater deficitsHigh riskClinical InterviewFull psychotic disorderDeficitsSpecific subdomainsSRGPPsychotic disordersPsychosisGestures
2012
The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
Corlett PR, Fletcher PC. The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people. Neuropsychologia 2012, 50: 3612-3620. PMID: 23079501, PMCID: PMC3694307, DOI: 10.1016/j.neuropsychologia.2012.09.045.Peer-Reviewed Original ResearchConceptsHealthy peopleSymptoms of psychosisPsychotic illnessEarly psychosisHealthy individualsPsychosis showHealthy beliefsAdditional alterationsNeural markersNeural responsesSymptomsPsychosisNovel evidenceDelusional ideationDistressSchizotypal experiencesAlterationsPatientsPrevious observationsIllness
2007
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray G, Corlett P, Clark L, Pessiglione M, Blackwell A, Honey G, Jones P, Bullmore E, Robbins T, Fletcher P. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular Psychiatry 2007, 13: 267-276. PMID: 17684497, PMCID: PMC2564111, DOI: 10.1038/sj.mp.4002058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCase-Control StudiesChoice BehaviorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleModels, PsychologicalNeuropsychological TestsOxygenPhotic StimulationPsychiatric Status Rating ScalesPsychotic DisordersRewardSubstantia NigraVentral Tegmental AreaConceptsDopaminergic midbrainFunctional magnetic resonance imagingReward prediction errorHealthy control participantsPsychosis patientsNeutral stimuliMotivational salienceNeural responsesMental experienceRecent theoretical interestFirst-episode psychosis patientsPrediction errorConditioning experimentsControl participantsEpisode psychosis patientsPsychotic experiencesPathophysiology of schizophreniaPositive symptomsAbnormal physiological responsesMesolimbic activityMidbrain dopamine neuronsMagnetic resonance imagingDopamine dysfunctionDopamine systemDopamine neuronsPredictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers
Absalom A, Lee M, Menon D, Sharar S, De Smet T, Halliday J, Ogden M, Corlett P, Honey G, Fletcher P. Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers. British Journal Of Anaesthesia 2007, 98: 615-623. PMID: 17389691, PMCID: PMC3838936, DOI: 10.1093/bja/aem063.Peer-Reviewed Original ResearchConceptsTarget-controlled infusionKetamine infusionHealthy volunteersLow-dose ketamine infusionPlasma concentration-time courseVenous blood samplesCognitive function testsConcentration-time courseFunction testsKetamine administrationTarget concentrationBlood samplesKetamine modelInfusionMore occasionsTCI deviceFunctional neuroimagingVolunteers
2005
Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
Honey G, Pomarol-Clotet E, Corlett P, Honey R, Mckenna P, Bullmore E, Fletcher P. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 2005, 128: 2597-2611. PMID: 16183659, PMCID: PMC3838931, DOI: 10.1093/brain/awh632.Peer-Reviewed Original ResearchConceptsCognitive dysmetria hypothesisPatient groupAnterior cingulateFunctional MRIContinuous performance taskFunctional dysconnectivitySchizophrenia patientsPositive symptomsNegative symptomsMedial superior frontal gyrusThalamo-cortical circuitsDistinct symptom profilesSupplementary motor areaCases of schizophreniaSuperior frontal gyrusFunctional imaging studiesTask-related connectivityGroups of subjectsIllness onsetControl subjectsFunctional deficitsMotor functionHealthy volunteersMotor areaFundamental abnormality