2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2005
Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens
Dalley J, Lääne K, Theobald D, Armstrong H, Corlett P, Chudasama Y, Robbins T. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 6189-6194. PMID: 15833811, PMCID: PMC556132, DOI: 10.1073/pnas.0502080102.Peer-Reviewed Original ResearchConceptsAppetitive Pavlovian learningEarly memory consolidationNMDA receptor antagonistNucleus accumbensPavlovian memoryPavlovian learningAppetitive learningAssociative processesMemory consolidationApproach behaviorInstrumental learningPavlovian conditioningAppetitive memoryFood rewardReceptor antagonistConditioning sessionsNMDA receptorsSpatial learningInstrumental processesGlutamatergic influencesEarly consolidationD2 receptor antagonist sulpirideReceptor antagonist sulpirideIntra-NAc infusionsLearning