2023
Transfusion-transmitted Babesia spp.: a changing landscape of epidemiology, regulation, and risk mitigation
Drews S, Kjemtrup A, Krause P, Lambert G, Leiby D, Lewin A, O'Brien S, Renaud C, Tonnetti L, Bloch E. Transfusion-transmitted Babesia spp.: a changing landscape of epidemiology, regulation, and risk mitigation. Journal Of Clinical Microbiology 2023, 61: e01268-22. PMID: 37750699, PMCID: PMC10595070, DOI: 10.1128/jcm.01268-22.Peer-Reviewed Original ResearchConceptsBlood productsWhole blood-derived platelet concentratesNon-endemic areasNon-endemic regionsTTB casesMost patientsRed blood cellsClinical presentationSevere illnessBlood donorsDead-end hostsTick-borne parasitesHuman transmissionEndemic regionsClinical settingEpidemiologyBlood cellsCase numbersPlatelet concentratesTransfusionRisk
2019
Persistence of Babesia microti Infection in Humans
Bloch EM, Kumar S, Krause PJ. Persistence of Babesia microti Infection in Humans. Pathogens 2019, 8: 102. PMID: 31319461, PMCID: PMC6789900, DOI: 10.3390/pathogens8030102.Peer-Reviewed Original ResearchTransfusion-transmitted babesiosisBabesia microti infectionBlood donor screeningImmune evasive strategiesPeripheral blood smearFifth of casesHost immune mechanismsNovel therapeutic measuresNovel preventive approachesHIV/AIDSTick-borne diseaseRed blood cellsSevere complicationsAnti-parasitic drugsBlood transfusionImmunocompetent individualsImmunosuppressive drugsDonor screeningMicroti infectionImmune mechanismsBlood donorsHealth burdenImmunoglobulin preparationsNew anti-parasitic drugsTherapeutic measures
2017
Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers
Stahl P, Poinsignon Y, Pouedras P, Ciubotaru V, Berry L, Emu B, Krause PJ, Mamoun C, Cornillot E. Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers. Journal Of Travel Medicine 2017, 25: tax073. PMID: 29394381, PMCID: PMC6927858, DOI: 10.1093/jtm/tax073.Peer-Reviewed Original ResearchConceptsIndirect immunofluorescence antibody testingBabesiosis casesB. microti antibodiesB. microtiTreatment of babesiosisImmunofluorescence antibody testingB. microti infectionNon-endemic areasDiagnosis of babesiosisMicroti antibodiesFebrile illnessImmunocompetent patientsRed blood cellsAntibody testingB. microti DNAPhysical examinationCase reportMedical historyMicroti infectionTick biteClinical informationEndemic areasPatient sourcePatientsBlood smears
2014
Blood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice
Krause PJ, Hendrickson JE, Steeves TK, Fish D. Blood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice. Transfusion 2014, 55: 593-597. PMID: 25251880, DOI: 10.1111/trf.12879.Peer-Reviewed Original ResearchConceptsTransfusion transmissionRed blood cellsBorrelia miyamotoiBlood transfusion transmissionMurine transfusion modelFever spirochete Borrelia miyamotoiSpirochete clearanceRecipient bloodC57BL/6 miceMouse recipientsTransfusion modelMouse modelTransfusionMurine bloodHuman infectionsWet mountLyme diseaseStudy designBlood cellsMiceMiyamotoiSpirochetemiaFever spirochetesBloodBodied ticks
2000
Babesiosis
Homer M, Aguilar-Delfin I, Telford S, Krause P, Persing D. Babesiosis. Clinical Microbiology Reviews 2000, 13: 451-469. DOI: 10.1128/cmr.13.3.451.Peer-Reviewed Original ResearchPossible pathogenic mechanismsAppropriate patient managementInfected red blood cellsSpecies of BabesiaMalaria-like diseaseWidespread blood parasitesRed blood cellsSilent infectionEpidemiological descriptionDisease manifestationsPatient managementImmunological responsePear-shaped formsSevere hemolysisDisease processPathogenic mechanismsHematotropic parasitesBabesia microtiBabesial parasitesDiagnostic testsBlood cellsVeterinary impactBabesia speciesGenus BabesiaIxodid ticksBabesiosis
Homer M, Aguilar-Delfin I, Telford S, Krause P, Persing D. Babesiosis. Clinical Microbiology Reviews 2000, 13: 451-469. PMID: 10885987, PMCID: PMC88943, DOI: 10.1128/cmr.13.3.451-469.2000.Peer-Reviewed Original ResearchConceptsSpecies of BabesiaMalaria-like diseaseWidespread blood parasitesPear-shaped formsPossible pathogenic mechanismsAppropriate patient managementInfected red blood cellsHematotropic parasitesVeterinary impactBabesia speciesGenus BabesiaIxodid ticksBabesial parasitesZoonotic diseaseRed blood cellsBabesia divergensSilent infectionAnimal hostsEpidemiological descriptionDisease manifestationsPatient managementImmunological responseSevere hemolysisB. microtiTransmission cycle