2024
Tafenoquine for Relapsing Babesiosis: A Case Series
Krause P, Rogers R, Shah M, Kang H, Parsonnet J, Kodama R, Vannier E. Tafenoquine for Relapsing Babesiosis: A Case Series. Clinical Infectious Diseases 2024, 79: 130-137. PMID: 38814096, PMCID: PMC11259219, DOI: 10.1093/cid/ciae238.Peer-Reviewed Original ResearchRelapsing babesiosisPolymerase chain reactionReal-time polymerase chain reactionImmunocompromised patientsTreatment of Plasmodium vivax malariaPlasmodium vivax malariaModel of acute infectionAntimicrobial agentsBlood smearsAnimal models of acute infectionsWeekly maintenance dosesAcquisition of resistanceAtovaquone-proguanilVivax malariaMalaria prophylaxisMaintenance doseLoading doseCase seriesDelayed clearanceAcute infectionTafenoquinePrevent relapseThin blood smearsLow dosesAnimal models
2022
Animal models of the immunology and pathogenesis of human babesiosis
Kumar A, Kabra A, Igarashi I, Krause P. Animal models of the immunology and pathogenesis of human babesiosis. Trends In Parasitology 2022, 39: 38-52. PMID: 36470781, DOI: 10.1016/j.pt.2022.11.003.Peer-Reviewed Original ResearchConceptsAnimal modelsHuman babesiosisBabesia infectionImmunological mechanismsModerate diseaseOrgan dysfunctionPathologic responseDisease complicationsAsymptomatic infectionSevere diseaseAnimal studiesInfectionPathological processesDiseaseBabesiosisBabesia speciesAnimalsDomestic animalsComplicationsDysfunctionPathogenesisImmunology
2021
Tick hypersensitivity and human tick‐borne diseases
Ng YQ, Gupte TP, Krause PJ. Tick hypersensitivity and human tick‐borne diseases. Parasite Immunology 2021, 43: e12819. PMID: 33428244, DOI: 10.1111/pim.12819.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsImmune responseBlood mealTick-borne diseasesGeneralized hypersensitivity reactionHuman tick-borne diseasesHost immune responseLocal hypersensitivity reactionsLaboratory animal modelsItch responseCausative pathogenTick exposureSuch vaccinesTick salivary proteinsAnimal modelsAnti-tick vaccinesMost vector-borne diseasesTick salivaHuman investigationsDiseaseTick attachmentFuture preventionBlood coagulationHypersensitivity studiesVaccine