2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
2011
Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain
Herman P, Sanganahalli BG, Hyder F, Eke A. Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain. NeuroImage 2011, 58: 1060-1069. PMID: 21777682, PMCID: PMC3705180, DOI: 10.1016/j.neuroimage.2011.06.082.Peer-Reviewed Original Research
2010
Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats
Horváth B, Lenzsér G, Benyó B, Németh T, Benkő R, Iring A, Hermán P, Komjáti K, Lacza Z, Sándor P, Benyó Z. Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats. PLOS ONE 2010, 5: e14477. PMID: 21217826, PMCID: PMC3013104, DOI: 10.1371/journal.pone.0014477.Peer-Reviewed Original ResearchMeSH Keywords15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsBrainCerebrovascular CirculationEnzyme InhibitorsHypersensitivityLaser-Doppler FlowmetryMaleMiddle Cerebral ArteryMotionNG-Nitroarginine Methyl EsterNitric OxideRatsRats, WistarReceptors, ThromboxaneRho-Associated KinasesSignal TransductionThromboxane A2ConceptsCerebral blood flowCBF oscillationsNitric oxideCerebral vasomotionThromboxane receptorNitro-L-arginine methyl esterDecreased cerebral blood flowMean arterial blood pressureEndothelium-derived nitric oxideTP receptor agonist UAbsence of NOCerebral circulatory parametersLow-frequency spontaneous fluctuationsArterial blood pressureTP receptor activationCerebrovascular toneEndothelial dysfunctionBlood pressureL-NAMEVascular effectsAgonist UNO deficiencyCirculatory parametersPharmacological modulationBlood flow
2009
Cerebral oxygen demand for short‐lived and steady‐state events
Herman P, Sanganahalli BG, Blumenfeld H, Hyder F. Cerebral oxygen demand for short‐lived and steady‐state events. Journal Of Neurochemistry 2009, 109: 73-79. PMID: 19393011, PMCID: PMC2714475, DOI: 10.1111/j.1471-4159.2009.05844.x.Peer-Reviewed Original ResearchOxidative Neuroenergetics in Event-Related Paradigms
Sanganahalli BG, Herman P, Blumenfeld H, Hyder F. Oxidative Neuroenergetics in Event-Related Paradigms. Journal Of Neuroscience 2009, 29: 1707-1718. PMID: 19211878, PMCID: PMC2760964, DOI: 10.1523/jneurosci.5549-08.2009.Peer-Reviewed Original Research
2008
Frequency‐dependent tactile responses in rat brain measured by functional MRI
Sanganahalli BG, Herman P, Hyder F. Frequency‐dependent tactile responses in rat brain measured by functional MRI. NMR In Biomedicine 2008, 21: 410-416. PMID: 18435491, PMCID: PMC2774500, DOI: 10.1002/nbm.1259.Peer-Reviewed Original Research
2007
Energetics of neuronal signaling and fMRI activity
Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F. Energetics of neuronal signaling and fMRI activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20546-20551. PMID: 18079290, PMCID: PMC2154468, DOI: 10.1073/pnas.0709515104.Peer-Reviewed Original ResearchConceptsRSN activityContralateral S1FMRI activationBaseline stateContralateral primary somatosensory cortexPrimary somatosensory cortexSomatosensory cortexIntracortical interactionsFiring rateNeuronal signalingFMRI activityEnsemble activityEnsemble firingStimulationHalothaneCortexNeuronsBaselineActivationFMRI dataLarge majorityAnesthesiaActivityRatsInfluence of the heme-oxygenase pathway on cerebrocortical blood flow
Leszl-Ishiguro M, Horváth B, Johnson R, Johnson F, Lenzsér G, Hermán P, Horváth E, Benyó Z. Influence of the heme-oxygenase pathway on cerebrocortical blood flow. Neuroreport 2007, 18: 1193-1197. PMID: 17589325, DOI: 10.1097/wnr.0b013e3282202459.Peer-Reviewed Original ResearchConceptsCerebrocortical blood flowNitric oxide synthaseEndogenous carbon monoxideBlood flowInhibition of NOSDirect vascular effectsHeme oxygenase pathwayCentral nervous systemNOS blockadeVascular effectsCBF responseOxide synthaseAdult ratsNervous systemHeme oxygenaseBlockadeRatsCurrent studyInhibitionHypercapniaLatter effectHypoxia
2006
Nonlinear Analysis of Blood Cell Flux Fluctuations in the Rat Brain Cortex during Stepwise Hypotension Challenge
Herman P, Eke A. Nonlinear Analysis of Blood Cell Flux Fluctuations in the Rat Brain Cortex during Stepwise Hypotension Challenge. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 1189-1197. PMID: 16395288, DOI: 10.1038/sj.jcbfm.9600266.Peer-Reviewed Original ResearchFractal and Noisy CBV Dynamics in Humans: Influence of Age and Gender
Eke A, Hermán P, Hajnal M. Fractal and Noisy CBV Dynamics in Humans: Influence of Age and Gender. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 891-898. PMID: 16292253, DOI: 10.1038/sj.jcbfm.9600243.Peer-Reviewed Original Research
2001
NO Synthase Blockade Induces Chaotic Cerebral Vasomotion via Activation of Thromboxane Receptors
Lacza Z, Hermán P, Görlach C, Hortobágyi T, Sándor P, Wahl M, Benyó Z. NO Synthase Blockade Induces Chaotic Cerebral Vasomotion via Activation of Thromboxane Receptors. Stroke 2001, 32: 2609-2614. PMID: 11692025, DOI: 10.1161/hs1101.098526.Peer-Reviewed Original ResearchConceptsThromboxane receptorL-NACerebral vasomotionThromboxane receptor agonist URat middle cerebral arteriesIntact vesselsGuanylyl cyclase inhibitor 1HNitro-L-arginineMiddle cerebral arteryNO-cGMP pathwayNO donor sodium nitroprussideDonor sodium nitroprussideLack of NOSignificant vasomotionUTP administrationEndothelial dysfunctionSynthase blockadeAgonist UCerebral arteryVascular tensionCerebrovascular diseaseVascular toneCerebral vesselsSynthase inhibitionSodium nitroprusside