2008
Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum
Elliott D, McIntosh M, Hosgood H, Chen S, Zhang G, Baevova P, Joiner K. Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 2463-2468. PMID: 18263733, PMCID: PMC2268159, DOI: 10.1073/pnas.0711067105.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsHemoglobinsMalariaMicroscopy, ImmunoelectronPlasmodium falciparumRab5 GTP-Binding ProteinsSchizontsTrophozoitesVacuoles
2007
Traffic to the Malaria Parasite Food Vacuole A NOVEL PATHWAY INVOLVING A PHOSPHATIDYLINOSITOL 3-PHOSPHATE-BINDING PROTEIN *
McIntosh M, Vaid A, Hosgood H, Vijay J, Bhattacharya A, Sahani M, Baevova P, Joiner K, Sharma P. Traffic to the Malaria Parasite Food Vacuole A NOVEL PATHWAY INVOLVING A PHOSPHATIDYLINOSITOL 3-PHOSPHATE-BINDING PROTEIN *. Journal Of Biological Chemistry 2007, 282: 11499-11508. PMID: 17289673, DOI: 10.1074/jbc.m610974200.Peer-Reviewed Original ResearchConceptsFYVE proteinFood vacuolesFYVE domain-containing proteinsDomain-containing proteinsZinc finger motifsParasite food vacuoleHigher eukaryotesEndosomal proteinFinger motifSecretory pathwayParasite cytosolDeletion mutantsDomain familyEndocytic organellesRegulatory proteinsKey residuesMutagenesis studiesPeptide domainBinding proteinLysosomal compartmentNovel pathwayFunctional roleProteinKey ligandPathway
2004
The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation
Yang M, Coppens I, Wormsley S, Baevova P, Hoppe H, Joiner K. The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation. Journal Of Cell Science 2004, 117: 3831-3838. PMID: 15252121, DOI: 10.1242/jcs.01237.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAdenosine TriphosphateAnimalsCell ProliferationCholesterolCloning, MolecularCOS CellsCytoplasmCytosolDNAElectroporationEndosomal Sorting Complexes Required for TransportEndosomesFibroblastsGreen Fluorescent ProteinsHumansHydrolysisImmunoblottingLipoproteins, LDLMicroscopy, ElectronMutationPhylogenyPlasmodium falciparumProtein Structure, TertiaryProtozoan ProteinsSubcellular FractionsToxoplasmaTransfectionTransgenesConceptsMultivesicular bodiesCOS cellsRelated parasite Toxoplasma gondiiUnique secretory organellesClass E genesMultivesicular body formationEndosomal multivesicular bodiesHost cell invasionLarge vesicular structuresPlasmodium falciparum homologP. falciparumVps4 functionEndosomal intermediatesApicomplexan familyPhylogenetic boundariesATP bindingSecretory organellesEarly endosomesParasite Toxoplasma gondiiP. falciparum trophozoitesATP hydrolysisInternal membranesT. gondiiBody formationCell invasion