1999
Limited Efficacy of Ketoconazole in Treatment-Refractory Major Depression
Malison R, Anand A, Pelton G, Kirwin P, Carpenter L, McDougle C, Heninger G, Price L. Limited Efficacy of Ketoconazole in Treatment-Refractory Major Depression. Journal Of Clinical Psychopharmacology 1999, 19: 466-470. PMID: 10505589, DOI: 10.1097/00004714-199910000-00011.Peer-Reviewed Original ResearchConceptsTreatment-refractory major depressionClinical Global Impression ScaleBeck Depression InventoryMajor depressionLimited efficacyTreatment-refractory major depressive disorderPlacebo-controlled trialGlobal Impression ScaleEfficacy of ketoconazoleHamilton Rating ScaleMajor depressive disorderAssessment of moodCGI scoresImpression ScaleDepressive disorderPatientsDepression InventoryRating ScaleKetoconazolePlaceboDepressionEfficacySignificant reductionTrials
1998
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Carpenter L, Anderson G, Pelton G, Gudin J, Kirwin P, Price L, Heninger G, McDougle C. Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects. Neuropsychopharmacology 1998, 19: 26-35. PMID: 9608574, DOI: 10.1016/s0893-133x(97)00198-x.Peer-Reviewed Original ResearchConceptsAmino acid drinkCerebrospinal fluidAcid drinkTRP levelsLow TRP dietTryptophan depletion paradigmBrain serotonin levelsPlasma TRP levelsHealthy adult subjectsHealthy human subjectsCSF TRP levelsPlasma TrpIndwelling catheterLumbar punctureSerotonin levelsTryptophan depletionContinuous cerebrospinal fluidSpecial dietAdult subjectsBehavioral effectsPlasma samplesHuman subjectsCorresponding fallCentral levelNadir
1997
Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females
Kirwin P, Anderson G, Chappell P, Saberski L, Leckman J, Geracioti T, Heninger G, Price L, McDougle C. Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females. Life Sciences 1997, 60: 899-907. PMID: 9061047, DOI: 10.1016/s0024-3205(97)00021-0.Peer-Reviewed Original ResearchConceptsCSF samplingCSF tryptophanNeuropsychiatric illnessCerebrospinal fluid tryptophanMultiple lumbar puncturesCerebrospinal fluid levelsPlasma TRP levelsRole of serotoninHealthy female volunteersLevels of tryptophanMajor neuropsychiatric disordersIntra-individual coefficientContinuous CSFCSF neurochemistryLumbar catheterLumbar puncturePlasma tryptophanHealthy subjectsTRP levelsFemale volunteersHealthy human femalesFluid levelsNeuropsychiatric disordersAnxiety disordersCSF