2001
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack D, Rakic P. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science 2001, 294: 2127-2130. PMID: 11739948, DOI: 10.1126/science.1065467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainBromodeoxyuridineCell DeathCell DivisionCell MovementEndothelium, VascularFemaleFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca fascicularisMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, FluorescenceNeocortexNeuronsNuclear ProteinsTubulinConceptsPrimate neocortexGlial cell markersAdult macaque monkeysNew neuronsNumerous BrdUOlfactory bulbCerebral wallAdult macaquesMacaque monkeysNonneuronal cellsHigher cognitive functionsCell markersCognitive functionNeocortexNeurogenesisTriple labelingCellular mechanismsCell proliferationNeuronsCellsHippocampusMode and Tempo of Tangential Cell Migration in the Cerebellar External Granular Layer
Komuro H, Yacubova E, Yacubova E, Rakic P. Mode and Tempo of Tangential Cell Migration in the Cerebellar External Granular Layer. Journal Of Neuroscience 2001, 21: 527-540. PMID: 11160432, PMCID: PMC6763794, DOI: 10.1523/jneurosci.21-02-00527.2001.Peer-Reviewed Original Research
2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABARadial Unit Hypothesis of Neocortical Expansion
Rakic P. Radial Unit Hypothesis of Neocortical Expansion. Novartis Foundation Symposia 2000, 228: 30-45. PMID: 10929315, DOI: 10.1002/0470846631.ch3.Peer-Reviewed Original ResearchConceptsRadial unit hypothesisSpecies-specific sizeFamily of genesMutations of genesVentricular zoneMammalian evolutionFounder cellsNatural selectionRegulatory genesCell divisionMorphoregulatory moleculesPostmitotic cellsTransgenic animalsCortical plateCell deathNeocortical expansionGenesBasic organizationGlial scaffoldingColumnar unitsCortical cellsCerebral cortexCellsCortical developmentSynaptic connections
1999
Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1
Haydar T, Bambrick L, Krueger B, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1. Brain Research 1999, 4: 425-437. PMID: 10592354, DOI: 10.1016/s1385-299x(99)00033-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBromodeoxyuridineCell DivisionCell MovementCell SurvivalFemaleFetusFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinIn Situ Nick-End LabelingMiceMice, Inbred ICRMicroscopy, ConfocalMicrotubule-Associated ProteinsNeocortexNeurogliaNeuronsOrgan Culture TechniquesPregnancyConceptsCell deathProper cortical developmentCell-cell interactionsDynamic cellular interactionsQuantitative confocal microscopyDiffusible regulatorsPrimary cell culturesAnalysis of proliferationCellular interactionsCellular mechanismsCortical neurogenesisNeuronal migrationConfocal microscopyCell proliferationNeocortical neurogenesisExperimental manipulationThree-dimensional environmentVivo processesCell culturesNeurogenesisPhysiological methodsTropic supportOrganotypic slice culturesProliferationCortical development
1998
Changes in cell-cycle kinetics during the development and evolution of primate neocortex
Kornack D, Rakic P. Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1242-1246. PMID: 9448316, PMCID: PMC18732, DOI: 10.1073/pnas.95.3.1242.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBromodeoxyuridineCell CycleCell DivisionDNA ReplicationFemaleMacaca mulattaMaleMiceNeocortexPregnancyS PhaseConceptsCell divisionCell division cycleCell cycle kineticsProgenitor cell divisionCell cycle lengthCell cycle durationEvolutionary modificationsEvolutionary expansionCerebral ventricular zoneDevelopmental basisCell productionPrimate neocortexS-phase labelingAnthropoid primatesProgenitor cellsFetal rhesus monkeysNeurogenetic periodVentricular zoneNeocortical sizeCortical cellsNeurogenesisCortical developmentMonkey cortexTotal roundsCortical layers
1995
Neurotransmitter receptors in the proliferative zones of the developing primate occipital lobe
Lidow M, Rakic P. Neurotransmitter receptors in the proliferative zones of the developing primate occipital lobe. The Journal Of Comparative Neurology 1995, 360: 393-402. PMID: 8543647, DOI: 10.1002/cne.903600303.Peer-Reviewed Original ResearchConceptsCortical neuronsOccipital lobeReceptor subtypesSubventricular zoneHigh-affinity kainate receptorsProliferative zoneSubventricular proliferative zonesNeurotransmitter receptor subtypesCell proliferationEmbryonic cerebral wallGamma-aminobutyric acidD1 dopaminergicMonkey fetusesDeep laminaeKainate receptorsNeuronal productionCerebral wallMultiple neurotransmittersCortical neurogenesisNeurotransmitter receptorsVisual cortexFetusesNeuronsAlpha 1Alpha 2A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution
Rakic P. A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution. Trends In Neurosciences 1995, 18: 383-388. PMID: 7482803, DOI: 10.1016/0166-2236(95)93934-p.Peer-Reviewed Original ResearchRadial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages
Kornack D, Rakic P. Radial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages. Neuron 1995, 15: 311-321. PMID: 7646888, DOI: 10.1016/0896-6273(95)90036-5.Peer-Reviewed Original Research
1994
Early neurogenesis in the anterior hypothalamus of the rhesus monkey
van Eerdenburg F, Rakic P. Early neurogenesis in the anterior hypothalamus of the rhesus monkey. Brain Research 1994, 79: 290-296. PMID: 7955328, DOI: 10.1016/0165-3806(94)90134-1.Peer-Reviewed Original ResearchConceptsAnterior hypothalamusRhesus monkeysNeurogenetic gradientsPrimate hypothalamusParaventricular nucleusGestational periodVentral gradientSupraoptic nucleusMonkey neuronsHypothalamusNeuronal generationNeuronsEarly neurogenesisSpecific nucleiNeurogenesisMonkeysEarly stagesSpecific differencesGestationNucleusWeeks
1988
Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey
Eckenhoff M, Rakic P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. Journal Of Neuroscience 1988, 8: 2729-2747. PMID: 3411351, PMCID: PMC6569394, DOI: 10.1523/jneurosci.08-08-02729.1988.Peer-Reviewed Original ResearchConceptsProliferative cellsMitotic divisionPostmitotic cellsUltra-structural characteristicsPossible functionsElectron microscopic levelStable populationGlial fibrillary acidic proteinNeuronal cellsStem cellsJuvenile periodMajor classesMature primatesSubgranular zoneDentate gyrusGlial cellsLife spanCellsGFAP-negative cellsFateRhesus monkeysAcidic proteinNew neuronsPostpubertal animalsFibrillary acidic proteinSpecification of Cerebral Cortical Areas
Rakic P. Specification of Cerebral Cortical Areas. Science 1988, 241: 170-176. PMID: 3291116, DOI: 10.1126/science.3291116.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAnimalsCell DivisionCell MovementCerebral CortexHumansNeuronal PlasticityNeuronsVisual CortexConceptsCytoarchitectonic areasCerebral ventricleEmbryonic cerebral ventriclesCerebral cortical areasHuman cerebral neocortexRadial unit hypothesisNeural transplantsReceptor autoradiographyAfferent inputCerebral neocortexCortical disordersGlial guidesCortical developmentCortical areasEpendymal layerProliferative unitsCell proliferationNeurobiological techniquesVentriclePhenotypic expressionLineage relationshipsCerebral evolutionRetrovirus gene transferGene transferTransplant
1985
DNA Synthesis and Cell Division in the Adult Primate Braina
RAKIC P. DNA Synthesis and Cell Division in the Adult Primate Braina. Annals Of The New York Academy Of Sciences 1985, 457: 193-211. PMID: 3913364, DOI: 10.1111/j.1749-6632.1985.tb20806.x.Peer-Reviewed Original ResearchConceptsPostembryonic neurogenesisNonmammalian vertebratesCell divisionDNA precursorsPrimate central nervous systemStable populationDNA synthesisNonprimate mammalsCentral nervous systemMature primatesNeuronal additionGlial cellsNervous systemAdult monkeysRetention of memoryAutoradiographic analysisMultiple injectionsVertebratesDevelopmental periodMammalsVariable degreesNeuronsJuvenilesNeurogenesisTurnover
1984
Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey
Eckenhoff M, Rakic P. Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey. The Journal Of Comparative Neurology 1984, 223: 1-21. PMID: 6707248, DOI: 10.1002/cne.902230102.Peer-Reviewed Original Research
1983
Gradients of cellular maturation and synaptogenesis in the superior colliculus of the fetal rhesus monkey
Cooper M, Rakic P. Gradients of cellular maturation and synaptogenesis in the superior colliculus of the fetal rhesus monkey. The Journal Of Comparative Neurology 1983, 215: 165-186. PMID: 6853771, DOI: 10.1002/cne.902150205.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell DivisionMacaca mulattaMicroscopy, ElectronSuperior ColliculiSynapsesConceptsSuperficial superior colliculus
1981
The total number, time of origin and kinetics of proliferation of neurons comprising the deep cerebellar nuclei in the rhesus monkey
Gould B, Rakic P. The total number, time of origin and kinetics of proliferation of neurons comprising the deep cerebellar nuclei in the rhesus monkey. Experimental Brain Research 1981, 44: 195-206. PMID: 7286107, DOI: 10.1007/bf00237341.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyCell CountCell DivisionCerebellar NucleiFetusMacaca mulattaNeuronsThymidineConceptsCerebellar nucleiPosterior interposed nucleusDeep nucleiSmall neuronsDentate nucleusFastigial nucleusRhesus monkeysInterposed nucleusCessation of neurogenesisGenesis of neuronsPostnatal rhesus monkeysIntermediate time courseDay gestation periodDeep cerebellar nucleiPostnatal ageCerebellar cortexAxonal connectionsOld monkeysNeuron populationsKinetics of proliferationNeuronsAutoradiographic methodTotal numberNeurogenesisPeak of proliferationCoexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis
Levitt P, Cooper M, Rakic P. Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis. Journal Of Neuroscience 1981, 1: 27-39. PMID: 7050307, PMCID: PMC6564162, DOI: 10.1523/jneurosci.01-01-00027.1981.Peer-Reviewed Original ResearchConceptsGlial fibrillary acid proteinLast cell divisionCell divisionRadial glial cellsNeuronal cell lineAcid proteinCerebral ventricular zoneEmbryonic day 80Proliferative zoneGlial precursor cellsMitotic cycleCell typesPeak of neurogenesisPrecursor cellsCell linesVentricular zoneElectron microscopic levelFetal monkeysProliferative cellsGlial cellsSubventricular zoneOccipital lobePhenotypic expressionCytological compositionDistinct classes
1979
Genesis of the primate neostriatum: [3H]thymidine autoradiographic analysis of the time of neuron origin in the rhesus monkey
Brand S, Rakic P. Genesis of the primate neostriatum: [3H]thymidine autoradiographic analysis of the time of neuron origin in the rhesus monkey. Neuroscience 1979, 4: 767-778. PMID: 113693, DOI: 10.1016/0306-4522(79)90005-8.Peer-Reviewed Original ResearchConceptsNeuron originSmall neuronsPrimate neostriatumRhesus monkeysEarly postnatal daysClasses of neuronsCell body diameterStriatal neurogenesisLarge cellsPostnatal daySingle coronal sectionsNeuronal distributionCaudate nucleusNeuronal proliferationCoronal sectionsDay 43Autoradiographic studyNeostriatumDay 36NeuronsAutoradiographic analysisMonkeysMaximum diameterPutamenDaysArrested proliferation of radial glial cells during midgestation in rhesus monkey
SCHMECHEL D, RAKIC P. Arrested proliferation of radial glial cells during midgestation in rhesus monkey. Nature 1979, 277: 303-305. PMID: 105294, DOI: 10.1038/277303a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DivisionCerebral CortexGestational AgeHaplorhiniNeurogliaOccipital LobeTelencephalonConceptsRadial glial cellsGlial cellsPial surfaceCerebral cortexGlial natureOccipital lobeTelencephalic wallEpendymal cellsGlial fibersRhesus monkeysNeuronal migrationCell classesAutoradiographic analysisVentricular surfaceAstrocytesTwo-thirdsMidgestationPresent studyCellsProliferationGestationPostnatalCerebrumCortexMonths
1978
Development of the interpeduncular nucleus in the midbrain of rhesus monkey and human
Lenn N, Halfon N, Rakic P. Development of the interpeduncular nucleus in the midbrain of rhesus monkey and human. Brain Structure And Function 1978, 152: 273-289. PMID: 418705, DOI: 10.1007/bf00350525.Peer-Reviewed Original ResearchConceptsInterpeduncular nucleusIPN neuronsRhesus monkeysCarnegie stages 17Histological preparationsNon-human primatesNeuronal sizeIntrauterine lifeCerebral aqueductPostmitotic cellsVentral midbrainGolgi impregnationNissl substanceDay 36Stage 17Golgi methodExperimental modelNeuronsNeuronal differentiationAutoradiographic methodAutoradiographic analysisVentricular surfaceMonkeysFinal cell divisionFetuses