2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrus
2009
Development of the Primate Cerebral Cortex
Rakic P, Arellano J, Breunig J. Development of the Primate Cerebral Cortex. 2009 DOI: 10.7551/mitpress/8029.003.0005.Peer-Reviewed Original ResearchCognitive neuroscienceProblem of qualiaComplex cognitionEmotional brainMemory researchPsychological realityConscious experienceExperience shapeFourth EditionLanguage facultyNeuroscienceFuture eventsMotor systemPrimate cerebral cortexCognitionFundamental stanceCentral tenetNew ideasLongstanding theoryMethodological workClassic referencesThird editionBaseline activityEmpirical evidenceTheoretical attempts
2001
Development of Layer I Neurons in the Primate Cerebral Cortex
Zecevic N, Rakic P. Development of Layer I Neurons in the Primate Cerebral Cortex. Journal Of Neuroscience 2001, 21: 5607-5619. PMID: 11466432, PMCID: PMC6762645, DOI: 10.1523/jneurosci.21-15-05607.2001.Peer-Reviewed Original ResearchConceptsCerebral cortexLayer ILayer I cellsLayer I neuronsPrimate cerebral cortexCajal-Retzius cellsSubpial granular layerGABAergic neuronsGABAergic interneuronsCortical plateI neuronsGanglionic eminenceMacaque monkeysPial surfaceOlfactory primordiumI cellsNeuronsMonth periodLong gestationGranular layerCortexUltrastructural analysisCorticogenesisCellsPrimates
1999
Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex. Cerebral Cortex 1999, 9: 586-600. PMID: 10498277, DOI: 10.1093/cercor/9.6.586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntisense Elements (Genetics)Brain ChemistryCloning, MolecularDNA-Binding ProteinsEphrin-A1FemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHomeodomain ProteinsIn Situ HybridizationMacaca mulattaNeocortexNeuronsPregnancyProsencephalonProteinsReceptor Protein-Tyrosine KinasesTranscription FactorsConceptsCerebral cortexPrimate cerebral cortexEmbryonic cerebral cortexMature cerebral cortexEphA receptor tyrosine kinasesArrival of afferentsPrimate forebrainCortical plateMature cortexEfferent connectionsCortical developmentCortical areasAnteroposterior extentSpecific afferentsMacaque monkeysReceptor tyrosine kinasesPeripheral influencesCortexGene expressionPrimate corticogenesisAfferentsNeocortexIntrinsic programCorticogenesisTyrosine kinaseMolecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex. Journal Of Neuroscience 1999, 19: 5967-5979. PMID: 10407035, PMCID: PMC6783094, DOI: 10.1523/jneurosci.19-14-05967.1999.Peer-Reviewed Original ResearchConceptsCortical platePresumptive visual cortexPrimate cerebral cortexLigand ephrin-A5Appropriate synaptic connectionsCortical cellsThalamocortical connectionsCerebral cortexMonkey neocortexCortical developmentPrimate neocortexVisual cortexSynaptic connectionsEphrin-A3Ephrin-A2Extrastriate cortexEarly gene expressionEmbryonic neocortexEphrin-A5Molecular patternsNeocortexCortexEphA6Primate corticogenesisPosterior region
1991
Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.
Lidow M, Goldman-Rakic P, Rakic P. Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 10218-10221. PMID: 1658799, PMCID: PMC52899, DOI: 10.1073/pnas.88.22.10218.Peer-Reviewed Original ResearchPlasticity of Cortical Development
Rakic P. Plasticity of Cortical Development. 1991, 125-159. DOI: 10.7551/mitpress/5415.003.0009.Peer-Reviewed Original ResearchEnvironmental signalsSpeech perceptionField of child psychologyPlasticity of developmentDevelopment of speech perceptionGenetic informationHuman speech perceptionDevelopmental processesDevelopmental continuityChild psychologyLanguage developmentAnimal learningHuman childrenPrimate cerebral cortexBrain developmentPhysiological correlatesOscine songbirdsRhesus monkeysEnvironmental nichesAdaptive significanceEpigenetic mechanismsCerebral cortexConcept of canalizationResponse to challengeEpigenetic programmingDistribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390
Lidow M, Goldman-Rakic P, Gallager D, Rakic P. Distribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390. Neuroscience 1991, 40: 657-671. PMID: 2062437, DOI: 10.1016/0306-4522(91)90003-7.Peer-Reviewed Original ResearchConceptsD2 receptorsCerebral cortexCytoarchitectonic areasDopaminergic receptorsLayer VLaminar distributionD1 receptorsD2 receptor distributionInfragranular layers VPresence of ketanserinPresence of mianserinNeurotransmitter receptor subtypesPrimate cerebral cortexD2 dopaminergic receptorsDifferent laminar distributionsMonkey cerebral cortexQuantitative autoradiographic analysisDopamine D1 receptorsDopamine D2 receptorsRostral-caudal gradientBilaminar patternLayer V.Motor cortexReceptor subtypesSpecific antagonist
1990
Autoradiographic comparison of D1-specific binding of [3H]SCH39166 and SCH23390 in the primate cerebral cortex
Lidow M, Goldman-Rakic P, Rakic P, Gallager D. Autoradiographic comparison of D1-specific binding of [3H]SCH39166 and SCH23390 in the primate cerebral cortex. Brain Research 1990, 537: 349-354. PMID: 2085785, DOI: 10.1016/0006-8993(90)90384-n.Peer-Reviewed Original ResearchConceptsPrimate cerebral cortexCis-flupentixolCerebral cortexNovel dopamine D1 receptor antagonistDopamine D1 receptor antagonistD1 receptor antagonistSpecific bindingD1 receptor subtypeMicroM SCH23390Receptor antagonistReceptor subtypesAutoradiographic comparisonOccipital cortexLaminar patternQuantitative autoradiographySCH23390CortexRadioligandHigh affinityNon-specific bindingAntagonistSCH39166AgentsSubtypesReceptorsAxon overproduction and elimination in the corpus callosum of the developing rhesus monkey
LaMantia A, Rakic P. Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey. Journal Of Neuroscience 1990, 10: 2156-2175. PMID: 2376772, PMCID: PMC6570389, DOI: 10.1523/jneurosci.10-07-02156.1990.Peer-Reviewed Original ResearchConceptsCallosal axonsAxon eliminationNewborn monkeysCorpus callosumRhesus monkeysCallosal projection zonePrimate cerebral cortexInterhemispheric projectionsCallosal projectionsCerebral cortexSynaptic densityPostnatal monthPostnatal weekSupernumerary axonsPostnatal eliminationMonkey cortexProjection zonesFetal developmentAdult valuesAxonsLocal proliferationCallosumDay 65BirthMonkeys
1986
Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex
Rakic P, Bourgeois J, Eckenhoff M, Zecevic N, Goldman-Rakic P. Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex. Science 1986, 232: 232-235. PMID: 3952506, DOI: 10.1126/science.3952506.Peer-Reviewed Original Research
1984
Region‐specific distribution of catecholamine afferents in primate cerebral cortex: A fluorescence histochemical analysis
Levitt P, Rakic P, Goldman‐Rakic P. Region‐specific distribution of catecholamine afferents in primate cerebral cortex: A fluorescence histochemical analysis. The Journal Of Comparative Neurology 1984, 227: 23-36. PMID: 6470208, DOI: 10.1002/cne.902270105.Peer-Reviewed Original ResearchConceptsCA innervationCerebral cortexCerebral lobesFluorescent axonsRhesus monkeysFirst anatomical demonstrationFluorescence histochemical analysisPrimate cerebral cortexSubjacent white matterPrimary visual cortexConcentration of DAAdult rhesus monkeysDifferent cortical regionsRegion-specific distributionLaminar distributionGyrencephalic brainLayer VICatecholamine afferentsSomatosensory areaFluorescence histochemistryPremotor areasCytoarchitectonic regionsIntracerebral distributionPreterminal axonsLayers IIOrganizing Principles for Development of Primate Cerebral Cortex
Rakic P. Organizing Principles for Development of Primate Cerebral Cortex. NATO Science Series A: 1984, 21-48. DOI: 10.1007/978-1-4684-4802-3_2.Peer-Reviewed Original Research