2001
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
Oppenheim R, Flavell R, Vinsant S, Prevette D, Kuan C, Rakic P. Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases. Journal Of Neuroscience 2001, 21: 4752-4760. PMID: 11425902, PMCID: PMC6762357, DOI: 10.1523/jneurosci.21-13-04752.2001.Peer-Reviewed Original ResearchConceptsCell deathGenetic deletionExtensive cytoplasmic vacuolizationPro-apoptotic proteasesCaspase familySpecific caspasesChromatin condensationNonapoptotic pathwaysPostmitotic neuronsCaspase-9Mammalian neuronsCell typesDeath processSpecific perturbationsCaspase-3Altered morphologyCaspasesNuclear changesKey membersDeletionUTP nickCytoplasmic vacuolizationElectron microscopic levelTerminal deoxynucleotidyl transferase-mediated biotinylated UTP nickNeuronal populations
2000
Mechanisms of programmed cell death in the developing brain
Kuan C, Roth K, Flavell R, Rakic P, Kuan C, Roth K, Flavell R, Rakic P. Mechanisms of programmed cell death in the developing brain. Trends In Neurosciences 2000, 23: 291-297. PMID: 10856938, DOI: 10.1016/s0166-2236(00)01581-2.Peer-Reviewed Original ResearchConceptsCell deathNematode Caenorhabditis elegansEarly embryonic developmentGene-targeting studiesCell death pathwaysVertebrate nervous systemMammalian brain developmentCaenorhabditis elegansEmbryonic developmentGenetic analysisPostmitotic neuronsBrain developmentNeural cell deathAnalogous functionsDistinct rolesProgenitor cellsMammalian brainApoptosisNew insightsImportant mechanismElegansHomologLater stagesNervous systemMechanism
1998
Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1995
The role of receptor/channel activity in neuronal cell migration
Rakic P, Komuro H. The role of receptor/channel activity in neuronal cell migration. Developmental Neurobiology 1995, 26: 299-315. PMID: 7775964, DOI: 10.1002/neu.480260303.Peer-Reviewed Original ResearchConceptsNeuronal cell migrationCell migrationIon channelsLocal cellular milieuSpecific ion channelsCell motilityCytoskeletal proteinsConfocal laser microscopyCellular milieuPostmitotic neuronsSecond messengerCellular mechanismsChannel activityLaser microscopyMotilitySynaptic connectionsExplant culturesEarly interactionsCellsFluorescent indicatorProteinMessengerMigrationPrior formationCarbocyanine dye
1992
Neurogenesis of the amygdaloid nuclear complex in the Rhesus monkey
Kordower J, Piecinski P, Rakic P. Neurogenesis of the amygdaloid nuclear complex in the Rhesus monkey. Brain Research 1992, 68: 9-15. PMID: 1521327, DOI: 10.1016/0165-3806(92)90242-o.Peer-Reviewed Original ResearchConceptsAmygdaloid complexRhesus monkeysAmygdaloid nucleusEmbryonic day 27Early postmitotic neuronsEarly postnatal periodAmygdaloid nuclear complexPregnant monkeysDays gestationPostnatal periodTemporal lobeVentral gradientDay 27Postmitotic neuronsNeurogenesisFirst neuronsNeuronsThymidine autoradiographyPrimate developmentMonkeysGestationNuclear complexTime coursePatterns of connectivityNeuroanatomical subdivisions