2009
Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling
Torii M, Hashimoto-Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature 2009, 461: 524-528. PMID: 19759535, PMCID: PMC2874978, DOI: 10.1038/nature08362.Peer-Reviewed Original ResearchConceptsNeocortical excitatory neuronsRadial glial fibersColumnar organizationEphA/ephrinCerebral cortexFunctional impairmentNeuronal clonesExcitatory neuronsGlial fibersTangential migrationCortical columnsNeural progenitorsCircuit developmentEphrinProliferative unitsPopulationClonal populationsCortexNeurons
1999
Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptors
1998
Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1997
Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migration
1996
Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall
Anton E, Cameron R, Rakic P. Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. Journal Of Neuroscience 1996, 16: 2283-2293. PMID: 8601808, PMCID: PMC6578523, DOI: 10.1523/jneurosci.16-07-02283.1996.Peer-Reviewed Original ResearchConceptsEmbryonic cerebral wallCerebral wallNeuronal migrationCerebral cortexNeuronal migratory pathwayRadial glial cell processesRadial glial fibersGlial cell processesNormal neuronal migrationCortical plateSlice preparationAntibody exposureGlial fibersMarginal zone regionsMonoclonal antibodiesAntibodiesNeuronsCortexCell substratesMarginal zonePolyclonal antiserumMicrotubular organizationCell processesMigratory pathwaysCell detachment
1988
Defects of neuronal migration and the pathogenesis of cortical malformations
Rakic P, Swaab D. Defects of neuronal migration and the pathogenesis of cortical malformations. Progress In Brain Research 1988, 73: 15-37. PMID: 3047794, DOI: 10.1016/s0079-6123(08)60494-x.Peer-Reviewed Original Research
1982
The Role of Neuronal-Glial Cell Interaction During Brain Development
Rakic P. The Role of Neuronal-Glial Cell Interaction During Brain Development. Dahlem Workshop Report 1982, 25-38. DOI: 10.1007/978-3-642-68466-1_4.Peer-Reviewed Original ResearchRadial glial cellsGlial cellsNeuronal-glial cell interactionsGlial-specific markersGlial cell classesRecent immunocytochemical studiesSite of originBrain abnormalitiesSynaptic terminalsGlial precursorsNervous systemPrimate brainGlial fibersImmunocytochemical studyBrain developmentDifferentiating neuronsCell classesBrain surfaceDegenerating cellsSpecific markersVentricular surfaceCellular mechanismsProliferative zonePossible involvementNormal developmental processes
1980
Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain
Levitt P, Rakic P. Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain. The Journal Of Comparative Neurology 1980, 193: 815-840. PMID: 7002963, DOI: 10.1002/cne.901930316.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinRadial glial cellsGlial cellsFibrillary acidic proteinBergmann glial cellsGlial fibersNeuronal elementsPial surfacePeroxidase-antiperoxidase immunohistochemical stainingAcidic proteinNeuronal migrationEmbryonic day 38Rhesus monkey brainSecond postnatal monthCentral nervous systemHorseradish peroxidase reaction productRadial fibersSpinal cordPostnatal monthBergmann glial fibersSubventricular zoneImmunohistochemical stainingAstroglial cellsCerebellar cortexImmunohistochemical localization
1979
A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes
Schmechel D, Rakic P. A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes. Brain Structure And Function 1979, 156: 115-152. PMID: 111580, DOI: 10.1007/bf00300010.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsCerebral wallSubventricular zoneOccipital lobeRadial fibersPial surfaceRadial glial fibersRapid Golgi methodMedial cerebral wallMonkey telencephalonCalcarine fissureCortical plateGolgi studyLateral ventricleProtoplasmic astrocytesLarge oval nucleiDay 365Ependymal cellsGlial fibersAstrocytesRhesus monkeysOlder ageDay 48Oval nucleiArrested proliferation of radial glial cells during midgestation in rhesus monkey
SCHMECHEL D, RAKIC P. Arrested proliferation of radial glial cells during midgestation in rhesus monkey. Nature 1979, 277: 303-305. PMID: 105294, DOI: 10.1038/277303a0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsPial surfaceCerebral cortexGlial natureOccipital lobeTelencephalic wallEpendymal cellsGlial fibersRhesus monkeysNeuronal migrationCell classesAutoradiographic analysisVentricular surfaceAstrocytesTwo-thirdsMidgestationPresent studyCellsProliferationGestationPostnatalCerebrumCortexMonths
1973
Neuronal migration, with special reference to developing human brain: a review
Sidman R, Rakic P. Neuronal migration, with special reference to developing human brain: a review. Brain Research 1973, 62: 1-35. PMID: 4203033, DOI: 10.1016/0006-8993(73)90617-3.Peer-Reviewed Original ResearchConceptsCerebellar cortexNervous systemRadial glial guidesGranule cell neuronsCentral nervous systemFetal human brainHuman brainImmunological definitionCerebral cortexCortical plateYoung neuronsAfferent axonsBergmann glial fibersGlial guidesCNS cellsGray nucleiGanglionic eminenceInferior oliveCell neuronsGlial fibersHuman nervous systemMutant miceNeuronal migrationNeuronsCortex