2014
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsCell DifferentiationCell MovementCells, CulturedFemaleGene ExpressionHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaNeural Cell Adhesion MoleculesNeural Stem CellsOxidative StressPhenotypePluripotent Stem CellsProsencephalonProteomicsReactive Oxygen SpeciesSchizophreniaYoung AdultConceptsHiPSC neural progenitor cellsNeural progenitor cellsHuman-induced pluripotent stem cellsHiPSC-derived neuronsGene expressionGene expression comparisonsStable isotope labelingProteomic mass spectrometry analysisAbnormal gene expressionPluripotent stem cellsOxidative stressCytoskeletal remodelingMass spectrometry analysisCellular phenotypesExpression comparisonsDevelopmental mechanismsIsotope labelingPhenotypic differencesBrainSpan AtlasDisease predispositionAmino acidsScalable assayNPC phenotypeStem cellsProgenitor cells
1991
Experimental manipulation of cerebral cortical areas in primates
Rakic P. Experimental manipulation of cerebral cortical areas in primates. Philosophical Transactions Of The Royal Society B Biological Sciences 1991, 331: 291-294. PMID: 1677473, DOI: 10.1098/rstb.1991.0019.Peer-Reviewed Original ResearchConceptsSpecies-specific diversityExperimental manipulationEmbryonic developmentPrimate embryosProtomap hypothesisDevelopmental mechanismsCellular eventsMolecular mechanismsNeuronal phenotypeCerebral cortical areasSynaptic architectureHigher brain functionsCell numberCerebral cortexCongenital disorderExtrinsic influencesSynaptic circuitryCortical areasCytoarchitectonic patternCytoarchitectonic areasBrain functionEmbryosDiversityDistinct areasPhenotype